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Information Journal Paper

Title

MicroRNA Prediction in the FVIII Gene Locus: A Step Towards Hemophilia A Control

Pages

  0-0

Abstract

 Background: Various mutations in factor VIII (F8) gene locus are led to an X-linked bleeding disorder in patients with Hemophilia A. Oneof the leading causes of inefficient treatment available for hemophiliaAis the lack of specificandsensitive diagnostic procedure for the disease. The discovery of a functional role of microRNAs (MiRNAs) in the pathogenesis of a wide range of human diseases makes them the potential, non-invasive, Biomarker candidates for Hemophilia A. Therefore, advances in computational tools for miRNA discovery leads to numerous recent publications on MiRNAs as putative Biomarkers. Objectives: The current study aimed at scanning the F8 gene region to predict novel MiRNAs as regulators of the F8 gene. Methods: The potential of the FVIII locus to express new MiRNAs was studied via reliable Bioinformatics databases, such as SSCprofiler, RNAfold, miREval, miR-Find, FOMmiR, UCSC genome browser, and miRBase. Results: Data analysis from previously mentioned databases offered two stem-loop structures predicted to express novel MiRNAs. Conclusions: The presented stem-loop structures can be used as powerful non-invasive Biomarkers in early Diagnosis of the disease and regulation of the factor VIII gene after subsequent experimental verification.

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    APA: Copy

    REZAEI, HALIMEH, MOTOVALI BASHI, MAJID, & Khalilian, Sheyda. (2020). MicroRNA Prediction in the FVIII Gene Locus: A Step Towards Hemophilia A Control. GENE, CELL AND TISSUE, 7(3), 0-0. SID. https://sid.ir/paper/697022/en

    Vancouver: Copy

    REZAEI HALIMEH, MOTOVALI BASHI MAJID, Khalilian Sheyda. MicroRNA Prediction in the FVIII Gene Locus: A Step Towards Hemophilia A Control. GENE, CELL AND TISSUE[Internet]. 2020;7(3):0-0. Available from: https://sid.ir/paper/697022/en

    IEEE: Copy

    HALIMEH REZAEI, MAJID MOTOVALI BASHI, and Sheyda Khalilian, “MicroRNA Prediction in the FVIII Gene Locus: A Step Towards Hemophilia A Control,” GENE, CELL AND TISSUE, vol. 7, no. 3, pp. 0–0, 2020, [Online]. Available: https://sid.ir/paper/697022/en

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