STUDY OF 4G/5G MUTATIONS PREVALENCE IN PLASMINOGEN ACTIVATOR INHIBITOR-1 (PAI-1) GENE IN IRANIAN WOMEN WITH ECTOPIC PREGNANCY

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SADEGHI ZAHRA; EBRAHIMI AHMAD; DAVARI TANHA FATEMEH; SEYEDENA SEYED YOUSEF

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Journal: Journal of Arak University Medical Sciences Year:2017 | Volume:20 | Issue:7 (124) Page(s): 43-53

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Title

STUDY OF 4G/5G MUTATIONS PREVALENCE IN PLASMINOGEN ACTIVATOR INHIBITOR-1 (PAI-1) GENE IN IRANIAN WOMEN WITH ECTOPIC PREGNANCY

Author(s)

SADEGHI ZAHRA | EBRAHIMI AHMAD | DAVARI TANHA FATEMEH | SEYEDENA SEYED YOUSEF | Issue Writer Certificate

Keywords

ECTOPIC PREGNANCYQ1

PLASMINOGEN ACTIVATOR INHIBITOR 1Q2

POLYMORPHISMQ1

RS1799889Q1

Abstract

Background: ECTOPIC PREGNANCY is a type of pregnancy in which implantation of zygote occurs out of the uterine cavity. One of the most important problems is bleeding. On the other hand, Plasminogen Activator Inhibitor-1 (PAI-1) gene is one of the involved factors in unsuccessful pregnancies, and 4G/5G POLYMORPHISM is the most common changes of this gene. So, it is important to study the prevalence of these changes in this gene in women with ECTOPIC PREGNANCY.Materials and Methods: In this case-control study, 100 Iranian women with ECTOPIC PREGNANCY and 101 Iranian women with the normal pregnancy were selected. After blood sampling, ARMS PCR method has been used for detection 4G/5G POLYMORPHISM and data were analyzed by statistical analysis.Results: In this study, 4G allele with 70.79% prevalence and 5G allele with 63.5% prevalence are the most common alleles for the control and case group, respectively.4G/4G and 4G/5G genotypes in the control group and 4G/5G and 5G/5G genotypes in the case group are prevalent. An Armitage test found p<0.05 for both alleles, showing 4G allele (p=1.524e-10; OR=0.262) has decreasing effect and 5G allele (p=1.524e-10; OR=3.822) has increasing effect in ECTOPIC PREGNANCY.Conclusion: According to the findings, 5G allele and 4G/5G and 5G/5G genotypes have increasing effect, 4G allele and 4G/4G genotype have decreasing effect in ECTOPIC PREGNANCY. So, we could consider 5G allele as a risk factor of ECTOPIC PREGNANCY in this study.

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References

RISK FACTORS IN ECTOPIC PREGNANCY: A CASE - CONTROL STUDY

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APA: Copy

SADEGHI, ZAHRA, EBRAHIMI, AHMAD, DAVARI TANHA, FATEMEH, & SEYEDENA, SEYED YOUSEF. (2017). STUDY OF 4G/5G MUTATIONS PREVALENCE IN PLASMINOGEN ACTIVATOR INHIBITOR-1 (PAI-1) GENE IN IRANIAN WOMEN WITH ECTOPIC PREGNANCY. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), 20(7 (124)), 43-53. SID. https://sid.ir/paper/69719/en

Vancouver: Copy

SADEGHI ZAHRA, EBRAHIMI AHMAD, DAVARI TANHA FATEMEH, SEYEDENA SEYED YOUSEF. STUDY OF 4G/5G MUTATIONS PREVALENCE IN PLASMINOGEN ACTIVATOR INHIBITOR-1 (PAI-1) GENE IN IRANIAN WOMEN WITH ECTOPIC PREGNANCY. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ)[Internet]. 2017;20(7 (124)):43-53. Available from: https://sid.ir/paper/69719/en

IEEE: Copy

ZAHRA SADEGHI, AHMAD EBRAHIMI, FATEMEH DAVARI TANHA, and SEYED YOUSEF SEYEDENA, “STUDY OF 4G/5G MUTATIONS PREVALENCE IN PLASMINOGEN ACTIVATOR INHIBITOR-1 (PAI-1) GENE IN IRANIAN WOMEN WITH ECTOPIC PREGNANCY,” ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), vol. 20, no. 7 (124), pp. 43–53, 2017, [Online]. Available: https://sid.ir/paper/69719/en

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