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Information Journal Paper

Title

Effect of High-Intensity Interval Training on Apoptotic Gene Expression in Rat Myocardial Tissue

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  0-0

Abstract

 Background: Excessive Apoptosis in the Myocardium contributes to the pathogenesis of heart disease. Evidence indicates that High-Intensity Interval Training (HIIT) can alter myocardial Apoptosis-related signaling. Objectives: The purpose of the study was to investigate the effect of 12 weeks of HIIT on some indices of Apoptosis, including Bcl-2, Bax, and caspase-3 in the myocardial tissue of male rats. Methods: Thirty male Wistar rats (age range: 8-10 weeks) were randomized into three groups, including sham (n = 10), control (n = 10), and HIIT (n = 10). The experimental group underwent HIIT consisting of 2-8 repetitions of 4-min high-intensity intervals (85%-90% peak speed) interspersed with low-intensity intervals (45%-50% peak speed), performed five times/week over 12 weeks. Forty-eight hours after the last training session, animals’ hearts were removed. The gene expressions of Bcl-2, Bax, and caspase-3 were analyzed by the RT-PCR method. The independent t-test was used for statistical analysis (P < 0. 05). Results: The gene expressions of Bcl-2 and Bcl-2/Bax ratio were higher in the training group than in the control group (P = 0. 001 and P = 0. 002, respectively). Regarding Bax and caspase-3 gene expression, although the mean levels were lower in the exercise group than in the control group, the differences were statistically insignificant (P = 0. 57 and P = 0. 27, respectively). Conclusions: Overall, it seems that HIIT significantly increases the expression of anti-apoptotic indicator Bcl-2 and the ratio of Bcl-2/Bax in the Myocardium of male rats. However, further studies are needed to show the effects of HIIT on myocardial Apoptosis.

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    APA: Copy

    POURRAZI, HASSAN, ASGHARPOUR ARSHAD, MASOUD, GHOLAMI, FARHAD, & ABBASI, SOHEILA. (2020). Effect of High-Intensity Interval Training on Apoptotic Gene Expression in Rat Myocardial Tissue. GENE, CELL AND TISSUE, 7(2), 0-0. SID. https://sid.ir/paper/697998/en

    Vancouver: Copy

    POURRAZI HASSAN, ASGHARPOUR ARSHAD MASOUD, GHOLAMI FARHAD, ABBASI SOHEILA. Effect of High-Intensity Interval Training on Apoptotic Gene Expression in Rat Myocardial Tissue. GENE, CELL AND TISSUE[Internet]. 2020;7(2):0-0. Available from: https://sid.ir/paper/697998/en

    IEEE: Copy

    HASSAN POURRAZI, MASOUD ASGHARPOUR ARSHAD, FARHAD GHOLAMI, and SOHEILA ABBASI, “Effect of High-Intensity Interval Training on Apoptotic Gene Expression in Rat Myocardial Tissue,” GENE, CELL AND TISSUE, vol. 7, no. 2, pp. 0–0, 2020, [Online]. Available: https://sid.ir/paper/697998/en

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