THE EFFECTS OF ZOLEDRONIC ACID TREATMENT ON DEPRESSION AND QUALITY OF LIFE IN WOMEN WITH POSTMENOPAUSAL OSTEOPOROSIS: A CLINICAL TRIAL STUDY

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GOKOSMANOGL FEYZI; Varim Ceyhun; Atmaca Aysegul; Atmaca Mehmet Hulusi; COLAK RAMIS

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Journal: JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS) Year:2016 | Volume:21 | Issue:8 Page(s): 0-0

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Title

THE EFFECTS OF ZOLEDRONIC ACID TREATMENT ON DEPRESSION AND QUALITY OF LIFE IN WOMEN WITH POSTMENOPAUSAL OSTEOPOROSIS: A CLINICAL TRIAL STUDY

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Keywords

DEPRESSION

OSTEOPOROSIS

QUALITY OF LIFE

Abstract

Background: OSTEOPOROSIS affects QUALITY OF LIFE (QoL) and may lead to DEPRESSION in women. The purpose of this study was to evaluate the effects of zoledronic acid (ZA) treatment on DEPRESSION and QoL in women with postmenopausal OSTEOPOROSIS (PO). Materials and Methods: A total of 88 newly diagnosed women with PO were included in this study. All patients were treated with once-yearly ZA (5 mg). A QoL questionnaire from the European Foundation for OSTEOPOROSIS and Beck DEPRESSION Inventory were given to patients at baseline and at 12 months. The results for baseline and post - 12th month were compared, and bone mineral density (BMD) levels were compared.Results: The consumption of once-yearly ZA (5 mg) treatment increases BMD at levels of lumbers 1-4 (P=0.026), total Hip T scores P value is same as femoral neck (P: 0, 033). ZA 5 mg treatment also improved QoL (P=0.001) and reduced DEPRESSION (P=0.001).Conclusion: ZA treatment increases BMD levels and QoL while reducing DEPRESSION. Once-yearly ZA (5 mg) may be considered for postmenopausal women as a first-line treatment.

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APA: Copy

GOKOSMANOGL, FEYZI, Varim, Ceyhun, Atmaca, Aysegul, Atmaca, Mehmet Hulusi, & COLAK, RAMIS. (2016). THE EFFECTS OF ZOLEDRONIC ACID TREATMENT ON DEPRESSION AND QUALITY OF LIFE IN WOMEN WITH POSTMENOPAUSAL OSTEOPOROSIS: A CLINICAL TRIAL STUDY. JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS), 21(8), 0-0. SID. https://sid.ir/paper/700224/en

Vancouver: Copy

GOKOSMANOGL FEYZI, Varim Ceyhun, Atmaca Aysegul, Atmaca Mehmet Hulusi, COLAK RAMIS. THE EFFECTS OF ZOLEDRONIC ACID TREATMENT ON DEPRESSION AND QUALITY OF LIFE IN WOMEN WITH POSTMENOPAUSAL OSTEOPOROSIS: A CLINICAL TRIAL STUDY. JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS)[Internet]. 2016;21(8):0-0. Available from: https://sid.ir/paper/700224/en

IEEE: Copy

FEYZI GOKOSMANOGL, Ceyhun Varim, Aysegul Atmaca, Mehmet Hulusi Atmaca, and RAMIS COLAK, “THE EFFECTS OF ZOLEDRONIC ACID TREATMENT ON DEPRESSION AND QUALITY OF LIFE IN WOMEN WITH POSTMENOPAUSAL OSTEOPOROSIS: A CLINICAL TRIAL STUDY,” JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS), vol. 21, no. 8, pp. 0–0, 2016, [Online]. Available: https://sid.ir/paper/700224/en

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