مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

PUNICA GRANATUM L. FRUIT AQUEOUS EXTRACT SUPPRESSES REACTIVE OXYGEN SPECIES-MEDIATED P53/P65/MIR-145 EXPRESSIONS FOLLOWED BY ELEVATED LEVELS OF IRS-1 IN ALLOXAN-DIABETIC RATS

Pages

  520-527

Abstract

 Objective: REACTIVE OXYGEN SPECIES (ROS) is an apoptosis inducer in pancreatic β-cells that stimulates P53/p65 mediated microRNA (miR) -145 expression.Punica granatum L. (pomegranate) is an antioxidant fruit that attenuates ROS generation. This study examines the effects of pomegranate fruit aqueous extract (PGE) on the levels of ROS, P53, P65, MIR-145, and its target insulin receptor substrate 1 (irs-1) mRNA in Alloxan-diabetic male Wistar rats.Materials and Methods: In this experimental study, diabetic rats received different doses of PGE. The effects of the PGE polyphenols were examined through a long-term PGE treatment period model, followed by an evaluation of the plasma and tissue contents of free fatty acids (FFAs), triglycerides (TG), and glycogen compared with diabetic controls (DC) and normal controls (NC). We used real-time polymerase chain reaction (PCR) to investigate the modulation of P53, P65, MIR-145, and irs-1 expression levels.Results: There was a noticeable reduction in fasting blood glucose (FBG) and ROS generation compared to DC.We observed marked decreases inp53, P65, MIR-145 expression levels followed by an elevated level of irs-1, which contributed to improvement in insulin sensitivity.Conclusion: PGE administration downregulated MIR-145 levels in Alloxan-diabetic Wistar rats by suppression of ROS-mediatedp53 and P65 overexpression.

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    APA: Copy

    GHARIB, EHSAN, MONTASSER KOUHSARI, SHIDEH, & IZAD, MARYAM. (2018). PUNICA GRANATUM L. FRUIT AQUEOUS EXTRACT SUPPRESSES REACTIVE OXYGEN SPECIES-MEDIATED P53/P65/MIR-145 EXPRESSIONS FOLLOWED BY ELEVATED LEVELS OF IRS-1 IN ALLOXAN-DIABETIC RATS. CELL JOURNAL (YAKHTEH), 19(4), 520-527. SID. https://sid.ir/paper/701553/en

    Vancouver: Copy

    GHARIB EHSAN, MONTASSER KOUHSARI SHIDEH, IZAD MARYAM. PUNICA GRANATUM L. FRUIT AQUEOUS EXTRACT SUPPRESSES REACTIVE OXYGEN SPECIES-MEDIATED P53/P65/MIR-145 EXPRESSIONS FOLLOWED BY ELEVATED LEVELS OF IRS-1 IN ALLOXAN-DIABETIC RATS. CELL JOURNAL (YAKHTEH)[Internet]. 2018;19(4):520-527. Available from: https://sid.ir/paper/701553/en

    IEEE: Copy

    EHSAN GHARIB, SHIDEH MONTASSER KOUHSARI, and MARYAM IZAD, “PUNICA GRANATUM L. FRUIT AQUEOUS EXTRACT SUPPRESSES REACTIVE OXYGEN SPECIES-MEDIATED P53/P65/MIR-145 EXPRESSIONS FOLLOWED BY ELEVATED LEVELS OF IRS-1 IN ALLOXAN-DIABETIC RATS,” CELL JOURNAL (YAKHTEH), vol. 19, no. 4, pp. 520–527, 2018, [Online]. Available: https://sid.ir/paper/701553/en

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