THE EFFECT OF BROMOCRIPTINE MESYLATE ON THE SEX BEHAVIOR AND CONCENTRATION OF TESTOSTRONE IN ADULT MALE RATS

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MOKHTARI M.; SAADATIAN M.

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Journal: JOURNAL OF SCIENCES (ISLAMIC AZAD UNIVERSITY) Year:2006 | Volume:15 | Issue:58/1 (BIOLOGY) Page(s): 516-527

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Title

THE EFFECT OF BROMOCRIPTINE MESYLATE ON THE SEX BEHAVIOR AND CONCENTRATION OF TESTOSTRONE IN ADULT MALE RATS

Author(s)

MOKHTARI M. | SAADATIAN M. | Issue Writer Certificate

Keywords

BROMOCRIPTINEQ4

SEXUAL BEHAVIORQ3

RATQ3

Abstract

BROMOCRIPTINE mesylate is a derivative of ergot alkaloids and shows Anti-effect Parkinsonism through dopaminergic receptors. This drug causes stimulating postsynaptic dopaminergic receptors in hypothalamus. BROMOCRIPTINE can be used as stimulator of ovulation in women. To our knowledge, this drug has not been used in men so we carried out an experiment on SEXUAL BEHAVIOR and concentration of testosterone in adult male RATs. Experiments have been done in a group of 50 male Wistar RAT weighing 200-220 gr, that were divided in Experimental, control and sham groups. Experimental groups received BROMOCRIPTINE mesylate about 0.25, 0.5, 1 (mg/kg), while Sham group received some drops of ethanol and distilled water and control group received nothing. Administration, continued during 20 days and sex behariours were studied. At the end of the day 20, blood Sampling was done and the serum concentration of testostrone was measured. The results were analyzed and studied by the method tukey-test and t-test. Statistical analysis showed that concentration of testosterone, sex motivation and sex performance in group administred BROMOCRIPTINE mesylate with does 0.5, 1 (mg/kg) in the comparison with control group has significantly increased at the end of the day 20 (p<0/05). With regard to the results, it seems that this drug causes the release of testosterone either through direct effect on leydig cells or through effect on luteotrop cells in adenohypophysis to release LH. This drug, probably with effect on medial-preoptic area, improves sex motivation and sex performance.

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APA: Copy

MOKHTARI, M., & SAADATIAN, M.. (2006). THE EFFECT OF BROMOCRIPTINE MESYLATE ON THE SEX BEHAVIOR AND CONCENTRATION OF TESTOSTRONE IN ADULT MALE RATS. JOURNAL OF SCIENCES (ISLAMIC AZAD UNIVERSITY), 15(58/1 (BIOLOGY)), 516-527. SID. https://sid.ir/paper/70219/en

Vancouver: Copy

MOKHTARI M., SAADATIAN M.. THE EFFECT OF BROMOCRIPTINE MESYLATE ON THE SEX BEHAVIOR AND CONCENTRATION OF TESTOSTRONE IN ADULT MALE RATS. JOURNAL OF SCIENCES (ISLAMIC AZAD UNIVERSITY)[Internet]. 2006;15(58/1 (BIOLOGY)):516-527. Available from: https://sid.ir/paper/70219/en

IEEE: Copy

M. MOKHTARI, and M. SAADATIAN, “THE EFFECT OF BROMOCRIPTINE MESYLATE ON THE SEX BEHAVIOR AND CONCENTRATION OF TESTOSTRONE IN ADULT MALE RATS,” JOURNAL OF SCIENCES (ISLAMIC AZAD UNIVERSITY), vol. 15, no. 58/1 (BIOLOGY), pp. 516–527, 2006, [Online]. Available: https://sid.ir/paper/70219/en

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