A Protocol for Recovery of Measles Virus from Intact/Recombinant Antigenomic DNA

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Alizadeh Roghayeh; GHANEI MOSTAFA; ARASHKIA ARASH; AZADMANESH KAYHAN

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Journal Paper

Paper Information

Journal: Pathobiology Research Year:2021 | Volume:24 | Issue:1 Page(s): 45-54

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Title

A Protocol for Recovery of Measles Virus from Intact/Recombinant Antigenomic DNA

Author(s)

Alizadeh Roghayeh | GHANEI MOSTAFA | ARASHKIA ARASH | AZADMANESH KAYHAN | Issue Writer Certificate

Keywords

Measles virus

Reverse genetics

Viral rescue

Oncolytic virotherapy

Abstract

Measles virus (MV), a negative-strand RNA virus, has been known as an ideal candidate for Oncolytic virotherapy. Recombinant MV could encode genes of interests to achieve several aims. Replication efficiency of oncolytic virus in tumor cells is a key parameter in efficient tumor eradication. Products of the P gene (P/V/C) support Measles virus to circumvent IFN 1 as the main response of the innate immune system against viruses. But vaccine strains used in Oncolytic virotherapy trials comprise several mutations in their P gene sequences. These mutations affect replication efficacy and cause the attenuation of measles strains applicable in vaccination. Thus, arming vaccine strains with a wild-type P gene is useful to achieve high viral titer. Here in this study, a fully detailed protocol was developed for efficient engineering and recovery of MV for different purposes.

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APA: Copy

Alizadeh, Roghayeh, GHANEI, MOSTAFA, ARASHKIA, ARASH, & AZADMANESH, KAYHAN. (2021). A Protocol for Recovery of Measles Virus from Intact/Recombinant Antigenomic DNA. PATHOBIOLOGY RESEARCH (MODARES JOURNAL OF MEDICAL SCIENCES), 24(1 ), 45-54. SID. https://sid.ir/paper/703351/en

Vancouver: Copy

Alizadeh Roghayeh, GHANEI MOSTAFA, ARASHKIA ARASH, AZADMANESH KAYHAN. A Protocol for Recovery of Measles Virus from Intact/Recombinant Antigenomic DNA. PATHOBIOLOGY RESEARCH (MODARES JOURNAL OF MEDICAL SCIENCES)[Internet]. 2021;24(1 ):45-54. Available from: https://sid.ir/paper/703351/en

IEEE: Copy

Roghayeh Alizadeh, MOSTAFA GHANEI, ARASH ARASHKIA, and KAYHAN AZADMANESH, “A Protocol for Recovery of Measles Virus from Intact/Recombinant Antigenomic DNA,” PATHOBIOLOGY RESEARCH (MODARES JOURNAL OF MEDICAL SCIENCES), vol. 24, no. 1 , pp. 45–54, 2021, [Online]. Available: https://sid.ir/paper/703351/en

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