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Information Journal Paper

Title

Evaluation of L-fucose and Sialic Acid Levels in Patients With Colorectal Cancer and Control Subject

Pages

  137-142

Keywords

CRC (colorectal cancer) 
AUC (area under curve) 
ROC (receiver operating characteristic) 

Abstract

 Background: Currently, glycans, which are known as functional molecules in the biological system, are being under study as potential cancer markers. This study aimed to determine the level of serum L-fucose and sialic acid as the biomarkers in patients with colorectal cancer (CRC). Materials and Methods: The patients with CRC (n=40, 20 men and 20 women) participated in the present study. The spectrophotometric method was used to measure the levels of L-fucose and sialic acid in the serum of the patients. SPSS v. 21 was used to analyze the obtained data. The results were expressed as Mean± SD. Results: The Mean± SD L-fucose level in patients with CRC was 27. 46± 4. 8 ng/mL, which was more than this level in the healthy control group (18. 64± 3. 1 ng/mL). Also, the Mean± SD serum concentration of sialic acid in patients with CRC was 2. 1± 0. 41 ng/mL, which was more than the Mean± SD sialic acid level of 1. 23± 0. 21 ng/mL in the healthy controls. Conclusion: Serum concentration of L-fucose and sialic acid increased significantly (P<0. 05) in patients with CRC compared with the healthy controls. We believe that determining serum L-fucose and sialic acid levels could be useful for the detection of CRC patients in the early stage.

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    Cite

    APA: Copy

    Abbasi Natajomrani, Roya, QUJEQ, DURDI, HOSSEINI, VAHID, & HAJIHOSSEINI, REZA. (2020). Evaluation of L-fucose and Sialic Acid Levels in Patients With Colorectal Cancer and Control Subject. RESEARCH IN MOLECULAR MEDICINE, 8(3), 137-142. SID. https://sid.ir/paper/704279/en

    Vancouver: Copy

    Abbasi Natajomrani Roya, QUJEQ DURDI, HOSSEINI VAHID, HAJIHOSSEINI REZA. Evaluation of L-fucose and Sialic Acid Levels in Patients With Colorectal Cancer and Control Subject. RESEARCH IN MOLECULAR MEDICINE[Internet]. 2020;8(3):137-142. Available from: https://sid.ir/paper/704279/en

    IEEE: Copy

    Roya Abbasi Natajomrani, DURDI QUJEQ, VAHID HOSSEINI, and REZA HAJIHOSSEINI, “Evaluation of L-fucose and Sialic Acid Levels in Patients With Colorectal Cancer and Control Subject,” RESEARCH IN MOLECULAR MEDICINE, vol. 8, no. 3, pp. 137–142, 2020, [Online]. Available: https://sid.ir/paper/704279/en

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