THE EFFECTS OF METABOLIC ALKALOSIS ON PITUITARY- ADERENAL AXIS AND IT'S INTERACTION WITH PITUITARY - GONAD AXIS IN INTACT AND ADRENALECTOMIZED ADULT MALE RATS

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KHATAMSAZ S.; ORYAN SHAHRBANOU; PARIVA K.; ROUHANI A.

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Paper Information

Journal: JOURNAL OF SCIENCES (ISLAMIC AZAD UNIVERSITY) Year:2004 | Volume:13 | Issue:50 Page(s): 4169-4188

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Title

THE EFFECTS OF METABOLIC ALKALOSIS ON PITUITARY- ADERENAL AXIS AND IT'S INTERACTION WITH PITUITARY - GONAD AXIS IN INTACT AND ADRENALECTOMIZED ADULT MALE RATS

Author(s)

KHATAMSAZ S. | ORYAN SHAHRBANOU | PARIVA K. | ROUHANI A. | Issue Writer Certificate

Keywords

METABOLIC ALKALOSISQ4

ADRENALECTOMY PITUITARY - ADRENAL AXISQ4

PITUITARY - GONAD AXISQ4

RATSQ4

Abstract

METABOLIC ALKALOSIS is among the commonest acid / base body fluids disorders; whose first symptom is increase of Hco-3 / PC02 ratio and body fluid pH. There are also namerous diseases, following METABOLIC ALKALOSIS, chief among which are Bartter’s syndrome, Gitelman’s syndrome, chronic/acute renal failure, chronic alcoholism and hyperaldostronism, This present research has studied the offects of METABOLIC ALKALOSIS on the function of pituitary - adrenal axis and PITUITARY - GONAD AXIS in intact and adrenalectomized adult male RATS. The RATS divides into 8 groups, each having 12 members as follows; main controle group, moderate sham, severe sham, moderate METABOLIC ALKALOSIS, severe METABOLIC ALKALOSIS, controle of adrenalectomy, adrenalectomy and adrenalectomy+ alkalosis. After the specific assigned for each groups (20 or 40 days), blood samples were taken to measure the pH and ACTH, Cortisol, LH, FSH and Testosterone concentration, using RIA method. The results show that pH level in blood of moderate and severe METABOLIC ALKALOSIS and andrenalectomy + alkalosis groups was significantly higher than that of the controle group. (p≤0.001) The concentration level of ACTH and cortisol was significantly higher in moderate and severe METABOLIC ALKALOSIS, and adrenalectomy + alkalosis.(P≤0.001).This result indicate higher activity of P A axis in this groups. The LH and testosterone concentration level was significantly lower in moderate and severe METABOLIC ALKALOSIS than that of the control group; which indicate a decrease in the function of PG axis following alkalosis. In adrenalectomy + alkalosis group, the concentration of LH and testosterone was also lower than that of the control group, which proves the direct effects of alkalocis on PG axis. The findings indicate that alkalosis causes deficiency in reproduction of adult male RATS through stimulating PA axis or the direct effect on PG axis.

Cites

SENSORY THRESHOLD OF PAIN IN MALE RATS BORN TO NORMAL MOTHERS AND MOTHERS WITH METABOLIC ALKALOSIS BY FORMALIN TEST

References

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APA: Copy

KHATAMSAZ, S., ORYAN, SHAHRBANOU, PARIVA, K., & ROUHANI, A.. (2004). THE EFFECTS OF METABOLIC ALKALOSIS ON PITUITARY- ADERENAL AXIS AND IT'S INTERACTION WITH PITUITARY - GONAD AXIS IN INTACT AND ADRENALECTOMIZED ADULT MALE RATS. JOURNAL OF SCIENCES (ISLAMIC AZAD UNIVERSITY), 13(50), 4169-4188. SID. https://sid.ir/paper/70449/en

Vancouver: Copy

KHATAMSAZ S., ORYAN SHAHRBANOU, PARIVA K., ROUHANI A.. THE EFFECTS OF METABOLIC ALKALOSIS ON PITUITARY- ADERENAL AXIS AND IT'S INTERACTION WITH PITUITARY - GONAD AXIS IN INTACT AND ADRENALECTOMIZED ADULT MALE RATS. JOURNAL OF SCIENCES (ISLAMIC AZAD UNIVERSITY)[Internet]. 2004;13(50):4169-4188. Available from: https://sid.ir/paper/70449/en

IEEE: Copy

S. KHATAMSAZ, SHAHRBANOU ORYAN, K. PARIVA, and A. ROUHANI, “THE EFFECTS OF METABOLIC ALKALOSIS ON PITUITARY- ADERENAL AXIS AND IT'S INTERACTION WITH PITUITARY - GONAD AXIS IN INTACT AND ADRENALECTOMIZED ADULT MALE RATS,” JOURNAL OF SCIENCES (ISLAMIC AZAD UNIVERSITY), vol. 13, no. 50, pp. 4169–4188, 2004, [Online]. Available: https://sid.ir/paper/70449/en

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