INTERACTION OF TRH AND BACIOFEN (AGONIST GABAB) ON CONSOLIDATION AND MEMORY RETENTION

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EYDI A.; PARIVAR KAZEM; ORYAN SHAHRBANOU; EYDI MARYAM

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Journal: JOURNAL OF SCIENCES (ISLAMIC AZAD UNIVERSITY) Year:2005 | Volume:14 | Issue:54 (BIOLOGY ISSU) Page(s): 4663-4671

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Title

INTERACTION OF TRH AND BACIOFEN (AGONIST GABAB) ON CONSOLIDATION AND MEMORY RETENTION

Author(s)

EYDI A. | PARIVAR KAZEM | ORYAN SHAHRBANOU | EYDI MARYAM | Issue Writer Certificate

Keywords

TRHQ4

BACLOFENQ4

MEMORYQ2

RATQ4

Abstract

TRH has an important role in the maintenance of consciousness and emotional or intellectual functions in the brain. The functional relation between TRH and cholinergic system and efficiency of TRH in treatment of amnesia are suggested. The binding sites of TRH found in limbic structures especially in septum and hippocampus GABA as an inhibitory neurotransmitter has an important effect on learning and MEMORY. The presence of GABA receptor in amygdala, medial septum and hippocampus is revealed.In this study, interaction between TRH and BACLOFEN (GABAB agonist) on MEMORY process through intra hippocampal microinjection and passive avoidance task in adult male RAT are evaluated. Bilateral microinjections into the dorsal hippocampus were carried out in all the experiments. After training of animal, TRH (1, 2.5, 5, 10 mg/ml), BACLOFEN (0.2, 0.3, 0.5, 1 mg/ml) and co-injection of TRH and BACLOFEN are injected. After a 48hr. period of time, the level of retention of MEMORY was measured. The results showed that TRH could be increase; BACLOFEN could be decrease and co-injection of TRH and BACLOFEN increase level of retention and consolidation of MEMORY.

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APA: Copy

EYDI, A., PARIVAR, KAZEM, ORYAN, SHAHRBANOU, & EYDI, MARYAM. (2005). INTERACTION OF TRH AND BACIOFEN (AGONIST GABAB) ON CONSOLIDATION AND MEMORY RETENTION. JOURNAL OF SCIENCES (ISLAMIC AZAD UNIVERSITY), 14(54 (BIOLOGY ISSU)), 4663-4671. SID. https://sid.ir/paper/70531/en

Vancouver: Copy

EYDI A., PARIVAR KAZEM, ORYAN SHAHRBANOU, EYDI MARYAM. INTERACTION OF TRH AND BACIOFEN (AGONIST GABAB) ON CONSOLIDATION AND MEMORY RETENTION. JOURNAL OF SCIENCES (ISLAMIC AZAD UNIVERSITY)[Internet]. 2005;14(54 (BIOLOGY ISSU)):4663-4671. Available from: https://sid.ir/paper/70531/en

IEEE: Copy

A. EYDI, KAZEM PARIVAR, SHAHRBANOU ORYAN, and MARYAM EYDI, “INTERACTION OF TRH AND BACIOFEN (AGONIST GABAB) ON CONSOLIDATION AND MEMORY RETENTION,” JOURNAL OF SCIENCES (ISLAMIC AZAD UNIVERSITY), vol. 14, no. 54 (BIOLOGY ISSU), pp. 4663–4671, 2005, [Online]. Available: https://sid.ir/paper/70531/en

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