BIOCHEMICAL AND HISTOLOGICAL EFFECTS OF ISCHEMIA ON THE SKELETAL MUSCLES OF RATS

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YAGHMAEI PARICHEHR; PARIVAR KAZEM; HAERI ROUHANI SEYED ALI; MONTASER KOUHSARI S.A.

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Journal: JOURNAL OF SCIENCES (ISLAMIC AZAD UNIVERSITY) Year:2005 | Volume:14 | Issue:54 (BIOLOGY ISSU) Page(s): 4609-4626

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Title

BIOCHEMICAL AND HISTOLOGICAL EFFECTS OF ISCHEMIA ON THE SKELETAL MUSCLES OF RATS

Author(s)

YAGHMAEI PARICHEHR | PARIVAR KAZEM | HAERI ROUHANI SEYED ALI | MONTASER KOUHSARI S.A. | Issue Writer Certificate

Keywords

ISCHEMIAQ4

SKELETAL MUSCLEQ4

FEMORAL ARTERYQ4

LIGATIONQ4

Abstract

Chronic Peripheral Occlusive Arterial Disease (CPOAD) which is caused by peripheral arterial insufficiency is usually due to arteriosclerosis. In this symptom disease the lower extremities are more involved than other parts of the body. Occlusion of the hind limb main arteries in rat is an experimental model of CPOAD. In the present experiment the effect of long term ISCHEMIA on the capillary of two hind limbs gastrocnemius muscle was investigated in Wistar rats (average weight 120±15gr). SKELETAL MUSCLE ISCHEMIA in the hind limb was induced by LIGATION (silk 3-0), or cautery of the left FEMORAL ARTERY. The right leg was applied as control The effect of ISCHEMIA was studied on the 3rd, 7th, 14th, 21st and 28th days after surgical operation in female and male groups (n=8). It was observed that the diameter & weight of the muscle/body were decreased. Histological studies revealed a decrease of the nuclei in size and number. Results from the electrophoresis (SDS-P AGE) and densitometry of protein bonds and enzyme gel electrophoresis showed that the quantity of the heavy myosin and actin chain in the ischemic muscle is decreased during different periods of the experiment, and this decrease is with a gradual trend. Likewise, the glycolytic anzymes decreased during the ISCHEMIA and some changes were observed in the catalase enzyme which was due to increase of peroxidation in the ischemic muscle cells, according to references.

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APA: Copy

YAGHMAEI, PARICHEHR, PARIVAR, KAZEM, HAERI ROUHANI, SEYED ALI, & MONTASER KOUHSARI, S.A.. (2005). BIOCHEMICAL AND HISTOLOGICAL EFFECTS OF ISCHEMIA ON THE SKELETAL MUSCLES OF RATS. JOURNAL OF SCIENCES (ISLAMIC AZAD UNIVERSITY), 14(54 (BIOLOGY ISSU)), 4609-4626. SID. https://sid.ir/paper/70536/en

Vancouver: Copy

YAGHMAEI PARICHEHR, PARIVAR KAZEM, HAERI ROUHANI SEYED ALI, MONTASER KOUHSARI S.A.. BIOCHEMICAL AND HISTOLOGICAL EFFECTS OF ISCHEMIA ON THE SKELETAL MUSCLES OF RATS. JOURNAL OF SCIENCES (ISLAMIC AZAD UNIVERSITY)[Internet]. 2005;14(54 (BIOLOGY ISSU)):4609-4626. Available from: https://sid.ir/paper/70536/en

IEEE: Copy

PARICHEHR YAGHMAEI, KAZEM PARIVAR, SEYED ALI HAERI ROUHANI, and S.A. MONTASER KOUHSARI, “BIOCHEMICAL AND HISTOLOGICAL EFFECTS OF ISCHEMIA ON THE SKELETAL MUSCLES OF RATS,” JOURNAL OF SCIENCES (ISLAMIC AZAD UNIVERSITY), vol. 14, no. 54 (BIOLOGY ISSU), pp. 4609–4626, 2005, [Online]. Available: https://sid.ir/paper/70536/en

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