ORAL QUERCETIN SUPPLEMENTATION ENHANCES ADIPONECTIN RECEPTOR TRANSCRIPT EXPRESSION IN POLYCYSTIC OVARY SYNDROME PATIENTS: A RANDOMIZED PLACEBO-CONTROLLED DOUBLE-BLIND CLINICAL TRIAL

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REZVAN NEDA; MOINI ASHRAF; GORGANI FIRUZJAEE SATTAR; HOSSEIN ZADEH ATTAR MOHAMMAD JAVAD

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Journal Paper

Paper Information

Journal: Cell Journal (Yakhteh) Year:2018 | Volume:19 | Issue:4 Page(s): 627-633

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Title

ORAL QUERCETIN SUPPLEMENTATION ENHANCES ADIPONECTIN RECEPTOR TRANSCRIPT EXPRESSION IN POLYCYSTIC OVARY SYNDROME PATIENTS: A RANDOMIZED PLACEBO-CONTROLLED DOUBLE-BLIND CLINICAL TRIAL

Author(s)

REZVAN NEDA | MOINI ASHRAF | GORGANI FIRUZJAEE SATTAR | HOSSEIN ZADEH ATTAR MOHAMMAD JAVAD | Issue Writer Certificate

Keywords

ADIPONECTIN RECEPTORS

POLYCYSTIC OVARY SYNDROME

QUERCETIN

Abstract

Objective: POLYCYSTIC OVARY SYNDROME (PCOS), an ovarian-pituitary axis androgen disorder, is a common endocrine disease in women. Obesity-induced androgenesis and imbalance of adipokine secretion may lead to some metabolic features of PCOS. The beneficial effects of polyphenolic compounds such as QUERCETIN have been reported, however, the underlying molecular mechanism is not entirely understood. In the present study, we investigated the effect of QUERCETIN supplementation on the expression of ADIPONECTIN RECEPTORS at the transcript level in peripheral blood mononuclear cells (PBMC) samples of PCOS patients.Materials and Methods: In this randomized clinical trial, 84 PCOS subjects were randomly assigned to two groups; the treatment group received 1 g QUERCETIN (two 500 mg capsules) daily for 12 weeks and the control group received placebo.To examine the effect of QUERCETIN supplementation on PCOS patients in addition to biochemical and anthropometric assessments, the expression ofADIPOR1 and ADIPOR2 at the transcript level and AMPK level were determined by quantitative reverse transcription-polymerase chain reaction (RT-qPCR) and ELISA assays respectively.Results: Oral QUERCETIN supplementation significantly increased ADIPOR1 and ADIPOR2 transcript expression by 1.32- and 1.46-fold respecetively (P<0.01). In addition, QUERCETIN supplementation enhanced AMPK level by 12.3% compared with the control group (P<0.05).Conclusion: Oral QUERCETIN supplementation improves the metabolic features of PCOS patients by upregulating the expression of ADIPONECTIN RECEPTORS and AMPK (Registration Number: IRCT2013112515536N1).

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APA: Copy

REZVAN, NEDA, MOINI, ASHRAF, GORGANI FIRUZJAEE, SATTAR, & HOSSEIN ZADEH ATTAR, MOHAMMAD JAVAD. (2018). ORAL QUERCETIN SUPPLEMENTATION ENHANCES ADIPONECTIN RECEPTOR TRANSCRIPT EXPRESSION IN POLYCYSTIC OVARY SYNDROME PATIENTS: A RANDOMIZED PLACEBO-CONTROLLED DOUBLE-BLIND CLINICAL TRIAL. CELL JOURNAL (YAKHTEH), 19(4), 627-633. SID. https://sid.ir/paper/706148/en

Vancouver: Copy

REZVAN NEDA, MOINI ASHRAF, GORGANI FIRUZJAEE SATTAR, HOSSEIN ZADEH ATTAR MOHAMMAD JAVAD. ORAL QUERCETIN SUPPLEMENTATION ENHANCES ADIPONECTIN RECEPTOR TRANSCRIPT EXPRESSION IN POLYCYSTIC OVARY SYNDROME PATIENTS: A RANDOMIZED PLACEBO-CONTROLLED DOUBLE-BLIND CLINICAL TRIAL. CELL JOURNAL (YAKHTEH)[Internet]. 2018;19(4):627-633. Available from: https://sid.ir/paper/706148/en

IEEE: Copy

NEDA REZVAN, ASHRAF MOINI, SATTAR GORGANI FIRUZJAEE, and MOHAMMAD JAVAD HOSSEIN ZADEH ATTAR, “ORAL QUERCETIN SUPPLEMENTATION ENHANCES ADIPONECTIN RECEPTOR TRANSCRIPT EXPRESSION IN POLYCYSTIC OVARY SYNDROME PATIENTS: A RANDOMIZED PLACEBO-CONTROLLED DOUBLE-BLIND CLINICAL TRIAL,” CELL JOURNAL (YAKHTEH), vol. 19, no. 4, pp. 627–633, 2018, [Online]. Available: https://sid.ir/paper/706148/en

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