DETERMINING THE FREQUENCY OF PANTON-VALENTINE LEUKOCIDIN (PVL GENES), AND COLLAGEN- BINDING PROTEIN (CNA) IN STAPHYLOCOCCUS AUREUS STRAINS ISOLATED FROM CLINICALSPECIMENS AND ANTIBIOTIC RESISTANCE: A SHORT REPORT

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KORD Z.; AMINI K.; PARVIZ M.

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Journal Paper

Paper Information

Journal: JOURNAL OF RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES Year:2015 | Volume:14 | Issue:8 Page(s): 701-708

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Title

DETERMINING THE FREQUENCY OF PANTON-VALENTINE LEUKOCIDIN (PVL GENES), AND COLLAGEN- BINDING PROTEIN (CNA) IN STAPHYLOCOCCUS AUREUS STRAINS ISOLATED FROM CLINICALSPECIMENS AND ANTIBIOTIC RESISTANCE: A SHORT REPORT

Author(s)

KORD Z. | AMINI K. | PARVIZ M. | Issue Writer Certificate

Keywords

STAPHYLOCOCCUS AUREUSQ2

PANTON -VALENTINE LEUKOCIDINQ2

CNAQ2

MULTIPLEX PCRQ2

Abstract

Background and Objective: Panton-Valentine leukocidin (PVL) toxin is a hemolytic exotoxin that increases the permeability of the cell membrane, thus causing lysis of leukocytes and tissue necrosis. Collagen-binding protein (Cna) adhesion STAPHYLOCOCCUS AUREUS is responsible for binding to collagen and the major virulence factor in arthritis and osteomyelitis. The purpose of this study was to investigate the presence of antibiotic resistance and virulence genes for PVL, CNA in STAPHYLOCOCCUS AUREUS strains isolated from clinical specimens by MULTIPLEX PCR.Materials and Methods: In this cross-sectional, descriptive study, 67 samples of STAPHYLOCOCCUS AUREUS were isolated.Based on CLSI antimicrobial susceptibility guidline, different antibiotics were tested. MULTIPLEX PCR assay was performed.Results: Finndings showed that the susceptibility to vancomycin and linezolid antibiotics was 97.1% and maximum resistance is to clindamycin was 23.9%. the frequency of CNA gene in clinical samples was 41.7% while PVL genes were not detected in the samples.Conclusion: Because of the importance of methicillin resistance STAPHYLOCOCCUS AUREUS as the cause of infection among people, especially resistant hospital infections, due to increasing use of antibiotics, knowledge of the level of resistance to these agents is essential. MULTIPLEX PCR is a simple, sensitive, inexpensive, relatively quick and very specific in addition, it has an ability to identify multiple genes simultaneously.

Cites

THE STUDY OF PANTONE VALENTIN LEUKOCIDIN (PVL) GENE IN METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS ISOLATED FROM BLOOD AND WOUND IN ZAHEDAN, IRAN

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APA: Copy

KORD, Z., AMINI, K., & PARVIZ, M.. (2015). DETERMINING THE FREQUENCY OF PANTON-VALENTINE LEUKOCIDIN (PVL GENES), AND COLLAGEN- BINDING PROTEIN (CNA) IN STAPHYLOCOCCUS AUREUS STRAINS ISOLATED FROM CLINICALSPECIMENS AND ANTIBIOTIC RESISTANCE: A SHORT REPORT. JOURNAL OF RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES, 14(8), 701-708. SID. https://sid.ir/paper/70815/en

Vancouver: Copy

KORD Z., AMINI K., PARVIZ M.. DETERMINING THE FREQUENCY OF PANTON-VALENTINE LEUKOCIDIN (PVL GENES), AND COLLAGEN- BINDING PROTEIN (CNA) IN STAPHYLOCOCCUS AUREUS STRAINS ISOLATED FROM CLINICALSPECIMENS AND ANTIBIOTIC RESISTANCE: A SHORT REPORT. JOURNAL OF RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES[Internet]. 2015;14(8):701-708. Available from: https://sid.ir/paper/70815/en

IEEE: Copy

Z. KORD, K. AMINI, and M. PARVIZ, “DETERMINING THE FREQUENCY OF PANTON-VALENTINE LEUKOCIDIN (PVL GENES), AND COLLAGEN- BINDING PROTEIN (CNA) IN STAPHYLOCOCCUS AUREUS STRAINS ISOLATED FROM CLINICALSPECIMENS AND ANTIBIOTIC RESISTANCE: A SHORT REPORT,” JOURNAL OF RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES, vol. 14, no. 8, pp. 701–708, 2015, [Online]. Available: https://sid.ir/paper/70815/en

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