VAGUE NERVE STIMULATION (VAGUE NERVE STIMULATION)

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Zangiabadi Nasser

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Journal Paper

Paper Information

Journal: Neuroscience Journal of Shefaye Khatam Year:2018 | Volume:6 | Issue:3 (SUPPLEMENT 2) Page(s): 18-18

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Information Journal Paper

Title

VAGUE NERVE STIMULATION (VAGUE NERVE STIMULATION)

Author(s)

Zangiabadi Nasser | Issue Writer Certificate

Keywords

VNS THERAPY

EPILEPSY

SYSTEMIC NEUROTOXIC EFFECTS

Abstract

VNS indicationsEpilepsyVNS THERAPY system is indicated for use as an adjunctive therapy in reducing the frequency of seizures in patients whose epileptic disorder is dominated by partial seizures (with or without secondary generalization) or generalized seizures that are refractory to antiepileptic medications.DepressionVNS THERAPY is indicated for the adjunctive long-term treatment of chronic or recurrent depression who are experiencing a major depressive episode and have not had an adequate response to four or more antidepressant treatments.Mechanism of actionVNS definitely exerts an effect via the LC (norepinephrine) and the RN (serotonin)These mechanisms of action are similar to those of medications through pharmacologic pathwaysThe LC and RN/DRN have been conclusively identified as:Brain centers affected by VNS THERAPYPlaying a role in suppressing seizuresAreas that must be intact for VNS THERAPY to have an effectVNS Safety ProfileMore than 70,000 patients worldwide have been implanted with VNS THERAPYNo known interactions with medicationsNo reported SYSTEMIC NEUROTOXIC EFFECTS, rash, renal impairment, or bone marrow suppressionNo increase in sudden, unexpected death in EPILEPSY (SUDEP)1Gestational outcomesAnimal study has shown no evidence of impaired fertility or harm to the fetus due to VNS THERAPY2,3Pregnancies have gone to term with VNS4,5One of my challenging Cases which resulted in Vague Nerve Stimulation (VNS) therapy53-year-old Right-handed gentleman with History of EPILEPSY since 1983 (due to being injured during war) in form of CPS and GTCsWe implanted VNS for the first time in Khatam-Al-Anbia hospital about three months ago for this patient.The frequency of the patient’s attacks has been decreased to about eighty percent till now.No significant side effects have been reported except for mild hoarseness.

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APA: Copy

Zangiabadi, Nasser. (2018). VAGUE NERVE STIMULATION (VAGUE NERVE STIMULATION). NEUROSCIENCE JOURNAL OF SHEFAYE KHATAM, 6(3 (SUPPLEMENT 2)), 18-18. SID. https://sid.ir/paper/708495/en

Vancouver: Copy

Zangiabadi Nasser. VAGUE NERVE STIMULATION (VAGUE NERVE STIMULATION). NEUROSCIENCE JOURNAL OF SHEFAYE KHATAM[Internet]. 2018;6(3 (SUPPLEMENT 2)):18-18. Available from: https://sid.ir/paper/708495/en

IEEE: Copy

Nasser Zangiabadi, “VAGUE NERVE STIMULATION (VAGUE NERVE STIMULATION),” NEUROSCIENCE JOURNAL OF SHEFAYE KHATAM, vol. 6, no. 3 (SUPPLEMENT 2), pp. 18–18, 2018, [Online]. Available: https://sid.ir/paper/708495/en

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