THE EFFECTS OF CCK-8 AND CCK2 RECEPTOR ANTAGONISTS ON NALOXONE-INDUCED JUMPING IN MORPHINE DEPENDENT MICE

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ROOHBAKHSH A.; ESMAEELI H.; ASAMI Z.; SHAMSIZADEH A.

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Journal: JOURNAL OF RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES Year:2011 | Volume:9 | Issue:4 (37) Page(s): 305-314

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Title

THE EFFECTS OF CCK-8 AND CCK2 RECEPTOR ANTAGONISTS ON NALOXONE-INDUCED JUMPING IN MORPHINE DEPENDENT MICE

Author(s)

ROOHBAKHSH A. | ESMAEELI H. | ASAMI Z. | SHAMSIZADEH A. | Issue Writer Certificate

Keywords

CHOLECYCTOKININQ2

MORPHINEQ2

DEPENDENCEQ2

PURE AGONISTQ3

COMPETITIVE ANTAGONISTQ3

JUMPINGSQ3

Abstract

Background and Objectives: Opioids are an important group of analgesics that are used extensively to control sever pains. Physical DEPENDENCE to these drugs is a major problem. There are a few studies regarding the involvement of CHOLECYCTOKININ (CCK) in the withdrawal syndromes of opioids. In the present study, the effects of CCK agonist and antagonist on the number of jumping of MORPHINE dependent mice were evaluated.Materials and Methods: In this experimental study, the effects of CCK-8 and LY225910 (selective CCK2 receptor antagonist) on JUMPINGS of mice after MORPHINE DEPENDENCE were evaluated. Mice were injected with MORPHINE three times a day (50, 50 and 75 mg/kg) for three days; at the forth day they received 50 mg/kg MORPHINE. Injection of naloxone (5 mg/kg) induced withdrawal signs such as jumping. The experimental groups received different doses of CCK-8 (0.1, 0.3 and 0.6 mg/kg) and LY225910 (0.01, 0.5 and 1 mg/kg) with each injection of MORPHINE.Results: Injection of CCK-8 significantly decreased the naloxone-induced JUMPINGS, while LY225910 did not have any significant effects on these JUMPINGS.Conclusions: Based on the results of the present study, activation of CCK1 receptors probably is involved in MORPHINE DEPENDENCE. The results also confirm that injection of CCK but not CCK2 selective antagonist probably decreases the JUMPINGS of mice following withdrawal syndrome of MORPHINE.

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APA: Copy

ROOHBAKHSH, A., ESMAEELI, H., ASAMI, Z., & SHAMSIZADEH, A.. (2011). THE EFFECTS OF CCK-8 AND CCK2 RECEPTOR ANTAGONISTS ON NALOXONE-INDUCED JUMPING IN MORPHINE DEPENDENT MICE. JOURNAL OF RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES, 9(4 (37)), 305-314. SID. https://sid.ir/paper/70859/en

Vancouver: Copy

ROOHBAKHSH A., ESMAEELI H., ASAMI Z., SHAMSIZADEH A.. THE EFFECTS OF CCK-8 AND CCK2 RECEPTOR ANTAGONISTS ON NALOXONE-INDUCED JUMPING IN MORPHINE DEPENDENT MICE. JOURNAL OF RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES[Internet]. 2011;9(4 (37)):305-314. Available from: https://sid.ir/paper/70859/en

IEEE: Copy

A. ROOHBAKHSH, H. ESMAEELI, Z. ASAMI, and A. SHAMSIZADEH, “THE EFFECTS OF CCK-8 AND CCK2 RECEPTOR ANTAGONISTS ON NALOXONE-INDUCED JUMPING IN MORPHINE DEPENDENT MICE,” JOURNAL OF RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES, vol. 9, no. 4 (37), pp. 305–314, 2011, [Online]. Available: https://sid.ir/paper/70859/en

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