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Information Journal Paper

Title

INSULIN GLARGINE AFFECTS THE EXPRESSION OF IGF-1R, INSR, AND IGF-1 GENES IN COLON AND LIVER OF DIABETIC RATS

Pages

  489-494

Abstract

 Objective (s): The mitogenic effect of the analogous INSULIN GLARGINE is currently under debate since several clinical studies have raised the possibility that INSULIN GLARGINE treatment has a carcinogenic potential in different tissues. This study aimed to evaluate theIgf-1r, Insr, and Igf-1 gene expression in COLON and LIVER of streptozotocin-induced diabetic RATS in response to INSULIN GLARGINE, neutral protamine Hagedorn (NPH) insulin, and METFORMIN treatments.Materials and Methods: Male Wistar RATS were induced during one week with streptozotocin to develop Type 2 DIABETES (T2D) and then randomly distributed into four groups. T2D RATS included in the first group received INSULIN GLARGINE, the second group received NPH INSULIN, the third group received METFORMIN; finally, untreated T2D RATS were included as the control group. All groups were treated for seven days; after the treatment, tissue samples of LIVER and COLON were obtained. Quantitative PCR (qPCR) was performed to analyze theIgf-1r, Insr and Igf-1 gene expression in each tissue sample.Results: The LIVER tissue showed overexpression of the Insr and Igf-1r genes (P>0.001) in RATS treated with INSULIN GLARGINE in comparison with the control group. Similar results were observed for the Insr gene (P>0.011) in COLONic tissue of RATS treated with INSULIN GLARGINE.Conclusion: These observations demonstrate that INSULIN GLARGINE promote an excess of insulin and IGF-1 receptors in STZ-induced diabetic RATS, which could overstimulate the mitogenic signaling pathways.

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    APA: Copy

    JUAREZ VAZQUEZ, CLARA I, GURROLA DIAZ, CARMEN M., VARGAS GUERRERO, BELINDA, DOMINGUEZ ROSALES, JOSE A., RODRIGUEZ ORTIZ, JESSICA F., BARROS-NUNEZ, PATRICIO, FLORES MARTINEZ, SILVIA E., SANCHEZ CORONA, JOSE, & ROSALES REYNOSO, MONICA A.. (2018). INSULIN GLARGINE AFFECTS THE EXPRESSION OF IGF-1R, INSR, AND IGF-1 GENES IN COLON AND LIVER OF DIABETIC RATS. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 21(5), 489-494. SID. https://sid.ir/paper/708888/en

    Vancouver: Copy

    JUAREZ VAZQUEZ CLARA I, GURROLA DIAZ CARMEN M., VARGAS GUERRERO BELINDA, DOMINGUEZ ROSALES JOSE A., RODRIGUEZ ORTIZ JESSICA F., BARROS-NUNEZ PATRICIO, FLORES MARTINEZ SILVIA E., SANCHEZ CORONA JOSE, ROSALES REYNOSO MONICA A.. INSULIN GLARGINE AFFECTS THE EXPRESSION OF IGF-1R, INSR, AND IGF-1 GENES IN COLON AND LIVER OF DIABETIC RATS. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2018;21(5):489-494. Available from: https://sid.ir/paper/708888/en

    IEEE: Copy

    CLARA I JUAREZ VAZQUEZ, CARMEN M. GURROLA DIAZ, BELINDA VARGAS GUERRERO, JOSE A. DOMINGUEZ ROSALES, JESSICA F. RODRIGUEZ ORTIZ, PATRICIO BARROS-NUNEZ, SILVIA E. FLORES MARTINEZ, JOSE SANCHEZ CORONA, and MONICA A. ROSALES REYNOSO, “INSULIN GLARGINE AFFECTS THE EXPRESSION OF IGF-1R, INSR, AND IGF-1 GENES IN COLON AND LIVER OF DIABETIC RATS,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 21, no. 5, pp. 489–494, 2018, [Online]. Available: https://sid.ir/paper/708888/en

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