EFFECT OF EXERCISE ON PAIN AND MORPHINE-INDUCED ANALGESIA IN THE FORMALIN TEST IN MALE MICE

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JAFARI H.; DARYANOUSH F.; ZARIFKAR A.; GHIASI E.; MOHAMMADI M.

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Journal: JOURNAL OF RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES Year:2014 | Volume:13 | Issue:1 Page(s): 97-108

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Title

EFFECT OF EXERCISE ON PAIN AND MORPHINE-INDUCED ANALGESIA IN THE FORMALIN TEST IN MALE MICE

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Keywords

ACUTE PAINQ2

CHRONIC PAINQ2

EXERCISEQ1

FORMALIN TESTQ3

MORPHINEQ2

Abstract

Background and Objective: Some studies have shown that different EXERCISEs reduce pain in different levels by affecting the levels of opioid. Therefore, we investigated the effect of EXERCISE on pain and MORPHINE-induced analgesia in the FORMALIN TEST in male mice.Materials and Methods: In this experimental study, 120 mice were randomly divided into 8 groups according to three different training sessions and uae of received MORPHINE or saline. The training program was conducted on a treadmill for30 minutes on the speed of 0.3 meters per second with different slopes. Thirty minutes before starting each EXERCISE, 5 mg of MORPHINE per kg of the animal weight was injected intraperitoneally. Finally, all groups were tested using the FORMALIN TEST. Data were analyzed using one-way ANOVA and post hoc Tukey test.Results: A significant reduction was found in response to painful stimuli in the acute phase (0-5 minutes) among the MORPHINE receiving groups (p=0.001). On the other hand, the response to painful stimuli in the CHRONIC PAIN phase(16-60 min) showed a signification reduction for the MORPHINE receiving groups as well as the EXERCISE group with a positive slope(p=0.015).Conclusion: If the intensity of EXERCISE can reach the threshold level required to stimulate the endogenous opioids, it is likely to reduce the feeling of pain. Furthermore, the effect of MORPHINE can not be influenced by the kind of EXERCISE.

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APA: Copy

JAFARI, H., DARYANOUSH, F., ZARIFKAR, A., GHIASI, E., & MOHAMMADI, M.. (2014). EFFECT OF EXERCISE ON PAIN AND MORPHINE-INDUCED ANALGESIA IN THE FORMALIN TEST IN MALE MICE. JOURNAL OF RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES, 13(1), 97-108. SID. https://sid.ir/paper/71045/en

Vancouver: Copy

JAFARI H., DARYANOUSH F., ZARIFKAR A., GHIASI E., MOHAMMADI M.. EFFECT OF EXERCISE ON PAIN AND MORPHINE-INDUCED ANALGESIA IN THE FORMALIN TEST IN MALE MICE. JOURNAL OF RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES[Internet]. 2014;13(1):97-108. Available from: https://sid.ir/paper/71045/en

IEEE: Copy

H. JAFARI, F. DARYANOUSH, A. ZARIFKAR, E. GHIASI, and M. MOHAMMADI, “EFFECT OF EXERCISE ON PAIN AND MORPHINE-INDUCED ANALGESIA IN THE FORMALIN TEST IN MALE MICE,” JOURNAL OF RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES, vol. 13, no. 1, pp. 97–108, 2014, [Online]. Available: https://sid.ir/paper/71045/en

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