THE EFFECTS OF ETHANOLIC EXTRACT OF ARTEMISIA OLIVERIANA ON EXPRESSION OF ICAA, ICAD, AND EBPS GENES IN MRSA: A SHORT REPORT

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SHOJAEI GH.; AKHAVAN SEPAHY A.; RAFIEI TABATABAEI R.; TAHVILDARI K.

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Paper Information

Journal: JOURNAL OF RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES Year:2018 | Volume:17 | Issue:2 Page(s): 169-176

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Title

THE EFFECTS OF ETHANOLIC EXTRACT OF ARTEMISIA OLIVERIANA ON EXPRESSION OF ICAA, ICAD, AND EBPS GENES IN MRSA: A SHORT REPORT

Author(s)

SHOJAEI GH. | AKHAVAN SEPAHY A. | RAFIEI TABATABAEI R. | TAHVILDARI K. | Issue Writer Certificate

Keywords

ARTEMISIA OLIVERIANAQ1

BIOFILMQ2

REAL-TIME PCRQ1

STAPHYLOCOCCUS AUREUSQ2

METHICILLINQ2

Abstract

Background and Objectives: Expression of genes related to BIOFILM formation in METHICILLIN-resistant STAPHYLOCOCCUS AUREUS (MRSA) can play an effective role in BIOFILM formation and pathogenicity. Due to the significance of antimicrobial activity of Artemisia species against BIOFILM producer genes, this study aimed to evaluate the effect of ethanolic extract of ARTEMISIA OLIVERIANA on the expression of icaA, icaD, and ebps genes in MRSA.Materials and Methods: This was a laboratory study. First, ARTEMISIA OLIVERIANA extract was prepared and then, the minimum inhibitory concentration (MIC) of growth for the extract of the plant againsts. aureus strains containing mecA was obtained by microdilution method. Then, at the lower concentrations, levels of expression in the icaA, icaD, and ebps genes in MRSA were determined by REAL-TIME PCR, and the results were analyzed through repeated measures ANOVA.Results: The MIC of ethanolic extract of A. oliveriana was 512 mg/ml. The reduction of the expression of the genes in the standard sample after 4, 8, and 16 hours was significant in the ARTEMISIA OLIVERIANA group (p<0.05).Conclusion: The ethanolic extracts of ARTEMISIA OLIVERIANA had a significant effect on the expression of the genes involved in BIOFILM formation and this expression reduction was not seen in the housekeeping DNA gyrase-B as a reference gene.

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APA: Copy

SHOJAEI, GH., AKHAVAN SEPAHY, A., RAFIEI TABATABAEI, R., & TAHVILDARI, K.. (2018). THE EFFECTS OF ETHANOLIC EXTRACT OF ARTEMISIA OLIVERIANA ON EXPRESSION OF ICAA, ICAD, AND EBPS GENES IN MRSA: A SHORT REPORT. JOURNAL OF RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES, 17(2 ), 169-176. SID. https://sid.ir/paper/71280/en

Vancouver: Copy

SHOJAEI GH., AKHAVAN SEPAHY A., RAFIEI TABATABAEI R., TAHVILDARI K.. THE EFFECTS OF ETHANOLIC EXTRACT OF ARTEMISIA OLIVERIANA ON EXPRESSION OF ICAA, ICAD, AND EBPS GENES IN MRSA: A SHORT REPORT. JOURNAL OF RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES[Internet]. 2018;17(2 ):169-176. Available from: https://sid.ir/paper/71280/en

IEEE: Copy

GH. SHOJAEI, A. AKHAVAN SEPAHY, R. RAFIEI TABATABAEI, and K. TAHVILDARI, “THE EFFECTS OF ETHANOLIC EXTRACT OF ARTEMISIA OLIVERIANA ON EXPRESSION OF ICAA, ICAD, AND EBPS GENES IN MRSA: A SHORT REPORT,” JOURNAL OF RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES, vol. 17, no. 2 , pp. 169–176, 2018, [Online]. Available: https://sid.ir/paper/71280/en

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