THE STUDY OF OXIDATIVE STRESS PARAMETERS AND LIVER ENZYMES IN EXPOSURE TO MULTI-WALL CARBON NANOTUBES IN RATS

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NASAJPOUR V.; NOORI A.; NAIERI H.

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Journal: Journal of Rafsanjan University of Medical Sciences Year:2018 | Volume:17 | Issue:5 Page(s): 447-460

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Title

THE STUDY OF OXIDATIVE STRESS PARAMETERS AND LIVER ENZYMES IN EXPOSURE TO MULTI-WALL CARBON NANOTUBES IN RATS

Author(s)

NASAJPOUR V. | NOORI A. | NAIERI H. | Issue Writer Certificate

Keywords

MULTI-WALL CARBON NANOTUBESQ1

OXIDATIVE STRESSQ2

LIVER ENZYMESQ2

RATQ2

Abstract

Background and Objectives: The proprietary of carbon nanotubes may cause harmful effects on the environment. In the present study, the effects of these nanoparticles on OXIDATIVE STRESS and liver function impairment in Wistar RATs were investigated.Materials and Methods: In this experimental study, the MULTI-WALL CARBON NANOTUBES functionalized with carboxylic groups were injected to Wistar RATs in 4 treatment groups (doses of 10 and 20 mg/kg/bw with two different blood sampling times) and control groups received physiological saline. Blood sampling was done in two stages, 24 hours and 144 hours after the last injection. Then, the activity levels of ALP (Alkaline phosphatase), ALT (Alanine aminotransferase), AST (Aspartate aminotransferase), LDH (Lactate dehydrogenase) enzymes, and malondialdehyde and plasma thiol levels were measured.Data were analyzed using one-way ANOVA and Duncan post hoc test.Results: In the first blood collection, LDH activity at the dose of 20 mg/kg and the amount of thiol groups at the dose of 10 mg/kg increased (p=0.006) and decreased (p=0.011) significantly than other groups, respectively. In the second blood collection, the activity levels of the ALP (p=0.020) and LDH (p=0.007) at a dose of 20 mg/kg and the activity levels of the ALT (p=0.033) at a dose of 10 mg/kg decreased significantly compared to the control group. The amount of malondialdehyde was significantly increased (p=0.023) at either doses of 10 and 20 mg/kg compared to the control group.Conclusion: Probably, carboxylic MULTI-WALL CARBON NANOTUBES, even at low doses, after 6 days of the last injection, causes disturbances in liver function by producing free radicals and OXIDATIVE STRESS.

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APA: Copy

NASAJPOUR, V., NOORI, A., & NAIERI, H.. (2018). THE STUDY OF OXIDATIVE STRESS PARAMETERS AND LIVER ENZYMES IN EXPOSURE TO MULTI-WALL CARBON NANOTUBES IN RATS. JOURNAL OF RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES, 17(5 ), 447-460. SID. https://sid.ir/paper/71308/en

Vancouver: Copy

NASAJPOUR V., NOORI A., NAIERI H.. THE STUDY OF OXIDATIVE STRESS PARAMETERS AND LIVER ENZYMES IN EXPOSURE TO MULTI-WALL CARBON NANOTUBES IN RATS. JOURNAL OF RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES[Internet]. 2018;17(5 ):447-460. Available from: https://sid.ir/paper/71308/en

IEEE: Copy

V. NASAJPOUR, A. NOORI, and H. NAIERI, “THE STUDY OF OXIDATIVE STRESS PARAMETERS AND LIVER ENZYMES IN EXPOSURE TO MULTI-WALL CARBON NANOTUBES IN RATS,” JOURNAL OF RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES, vol. 17, no. 5 , pp. 447–460, 2018, [Online]. Available: https://sid.ir/paper/71308/en

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