EVALUATION OF LEAD ACETATE EXPOSURE ON THE GROWTH AND EXPRESSION OF BAX IN CULTURED HUMAN EMBRYONIC ASTROCYTES

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

RAJABALIAN SAEID; SHAHI SADRABADI F.; DABIRI SH.; NEZHAD RAVARI A.; SALEHINEZHAD P.; HOSSEIN RAFAT

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: JOURNAL OF RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES Year:2008 | Volume:6 | Issue:4 (25) Page(s): 255-264

Download Full-Text

Persian Verion

View:

1,283

Download:

Cites:

Information Journal Paper

Title

EVALUATION OF LEAD ACETATE EXPOSURE ON THE GROWTH AND EXPRESSION OF BAX IN CULTURED HUMAN EMBRYONIC ASTROCYTES

Author(s)

Keywords

LEAD ACETATEQ2

CYTOTOXICITYQ2

ASTROCYTEQ2

BAXQ2

IMMUNOCYTOCHEMISTRYQ3

MTT ASSAYQ3

Abstract

Background and Objective: Lead (pb) is an environmental toxicant which can induce structural and functional abnormalities in central nervous system, specially in young children.Materials and Methods: In this experimental study, we evaluated the toxic effects of lead on human fetal ASTROCYTE cells. At the first stage, the growth inhibition effects of short and long term exposure to lead were evaluated by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Furthermore, the effect of Foetal Calf Serum (FCS) on lead toxicity was evaluated by above method. At the second stage, we applied IMMUNOCYTOCHEMISTRY (ICC) to analysis the effects of lead on the expression of stress related BAX gene.Results: The lead toxicity was observed at a concentration of >1mM (p=0.000). Continuous lead exposure also (250 and 500 mM for 7 days) caused a significant growth inhibition (p<0.01) of astroastes. The results showed the protective effect of FCS against lead toxicity. Lead exposure also induced BAX gene expression.Conclusion: These results show that lead may disturb the function of ASTROCYTEs and therefore and may interfere with development of fetal nervous system.

Cites

MYOCARDIAL INFLAMMATION AND DAMAGE INDUCED BY LEAD POLLUTION – T HE R OLE OF RESTRAIN REGULAR AEROBIC TRAINING

References

No record.

Cite

APA: Copy

RAJABALIAN, SAEID, SHAHI SADRABADI, F., DABIRI, SH., NEZHAD RAVARI, A., SALEHINEZHAD, P., & HOSSEIN, RAFAT. (2008). EVALUATION OF LEAD ACETATE EXPOSURE ON THE GROWTH AND EXPRESSION OF BAX IN CULTURED HUMAN EMBRYONIC ASTROCYTES. JOURNAL OF RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES, 6(4 (25)), 255-264. SID. https://sid.ir/paper/71368/en

Vancouver: Copy

RAJABALIAN SAEID, SHAHI SADRABADI F., DABIRI SH., NEZHAD RAVARI A., SALEHINEZHAD P., HOSSEIN RAFAT. EVALUATION OF LEAD ACETATE EXPOSURE ON THE GROWTH AND EXPRESSION OF BAX IN CULTURED HUMAN EMBRYONIC ASTROCYTES. JOURNAL OF RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES[Internet]. 2008;6(4 (25)):255-264. Available from: https://sid.ir/paper/71368/en

IEEE: Copy

SAEID RAJABALIAN, F. SHAHI SADRABADI, SH. DABIRI, A. NEZHAD RAVARI, P. SALEHINEZHAD, and RAFAT HOSSEIN, “EVALUATION OF LEAD ACETATE EXPOSURE ON THE GROWTH AND EXPRESSION OF BAX IN CULTURED HUMAN EMBRYONIC ASTROCYTES,” JOURNAL OF RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES, vol. 6, no. 4 (25), pp. 255–264, 2008, [Online]. Available: https://sid.ir/paper/71368/en

Related Journal Papers