DOSE-RESPONSE CHANGES OF BRASSICA OLERACEA VAR. ITALICA HYDROALCHOLIC EXTRACT IN THE CONTROL OF OXIDATIVE STRESS BY INDUCTION OF DIAZINON ON THE CELLS OF TESTICULAR TISSUE IN MALE ADULT RAT

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QADERI FOROUGH M.; RAEESZADEH M.; AMIRI A.A.

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Journal: Journal of Rafsanjan University of Medical Sciences Year:2017 | Volume:16 | Issue:7 Page(s): 593-604

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Title

DOSE-RESPONSE CHANGES OF BRASSICA OLERACEA VAR. ITALICA HYDROALCHOLIC EXTRACT IN THE CONTROL OF OXIDATIVE STRESS BY INDUCTION OF DIAZINON ON THE CELLS OF TESTICULAR TISSUE IN MALE ADULT RAT

Author(s)

QADERI FOROUGH M. | RAEESZADEH M. | AMIRI A.A. | Issue Writer Certificate

Keywords

OXIDATIVE STRESSQ2

BRASSICA OLERACEA VAR. ITALICA HYDROALCHOLIC EXTRACTQ1

DIAZINONQ2

TESTICULAR TISSUEQ2

RATQ2

Abstract

Background and Objectives: DIAZINON is one of the organophosphorus poisons that is widely used as insecticide and causes male infertility. The aim of this study was to evaluate the effects of broccoli hydroalcholic extract on the changes of the cells of TESTICULAR TISSUE and the control of OXIDATIVE STRESS by DIAZINON.Materials and Methods: In this experimental research, 30 adult male Wistar RATs weighing 200-250 gr were used. The control group receivied no treatment and the T1 group recievied the peritoneal administration of 30 mg/kg b.w DIAZINON and the other experimental groups (T2, T3, and T4) received diazonin as well as broccoli extract at dosage of 100, 200, and 300 mg/kg b.w, respectively for 28 days. At the end of the study, the animals were weighed and euthanized. The right testicle was used for histological study and the left testis for measuring malondialdehyde. The data was analyzed using one-way ANOVA and Tukey's post hoc test.Results: The lowest mean of body weight was 279.763±11.899 gr in the T1 group and the highest was 311.831±8.976 gr in the T4 group andit was observed a statistically significant difference (P=0.038). The number of the sertoli, spermatogonia, spermatocyt, and spermatides cells were 28.751±1.544, 60.501±4.828, 202.503±11.677, and 184.120±19.593, respectively in the T4 group. The highest number avarage was in the T4 group and the lowest in the T1 group (P=0.040). The highiest malondialdehyde concentration was 3.805 ± 0.017 in the T1 group and the lowest was 2.204 ± 0.056 μmol/ ml in the T4 group, which was significant (P<0.05).Conclusion: Broccoli extract at dosage of 300 mg/kg b.w has a positive effect on the spermatogenesis damage caused by DIAZINON in male RATs.

Cites

The study of the effect of hydroalcholic extracts of broccoli on lead induced oxidative stress in kidney of mice

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APA: Copy

QADERI FOROUGH, M., RAEESZADEH, M., & AMIRI, A.A.. (2017). DOSE-RESPONSE CHANGES OF BRASSICA OLERACEA VAR. ITALICA HYDROALCHOLIC EXTRACT IN THE CONTROL OF OXIDATIVE STRESS BY INDUCTION OF DIAZINON ON THE CELLS OF TESTICULAR TISSUE IN MALE ADULT RAT. JOURNAL OF RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES, 16(7 ), 593-604. SID. https://sid.ir/paper/71414/en

Vancouver: Copy

QADERI FOROUGH M., RAEESZADEH M., AMIRI A.A.. DOSE-RESPONSE CHANGES OF BRASSICA OLERACEA VAR. ITALICA HYDROALCHOLIC EXTRACT IN THE CONTROL OF OXIDATIVE STRESS BY INDUCTION OF DIAZINON ON THE CELLS OF TESTICULAR TISSUE IN MALE ADULT RAT. JOURNAL OF RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES[Internet]. 2017;16(7 ):593-604. Available from: https://sid.ir/paper/71414/en

IEEE: Copy

M. QADERI FOROUGH, M. RAEESZADEH, and A.A. AMIRI, “DOSE-RESPONSE CHANGES OF BRASSICA OLERACEA VAR. ITALICA HYDROALCHOLIC EXTRACT IN THE CONTROL OF OXIDATIVE STRESS BY INDUCTION OF DIAZINON ON THE CELLS OF TESTICULAR TISSUE IN MALE ADULT RAT,” JOURNAL OF RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES, vol. 16, no. 7 , pp. 593–604, 2017, [Online]. Available: https://sid.ir/paper/71414/en

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