مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

302
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

132
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

Information Journal Paper

Title

EFFECT OF (R)-(+) PULEGONE ON OVARIAN TISSUE; CORRELATION WITH EXPRESSION OF AROMATASE CYP19 AND OVARIAN SELECTED GENES IN MICE

Pages

  231-243

Abstract

 Objective: PULEGONE (PGN) is a monoterpene ketone, whose metabolites exert several cytotoxic effects in various tissues. The present study was conducted in order to evaluate the (R)-(+) PGN-induced alterations in ovarian AROMATIZATION, proto-oncogenes and estrogen receptorα (ERa) and ERβ receptors expressions.Materials and Methods: In this experimental study, mature albino MICE were divided into experimental (received 25 mg/kg, 50 mg/kg and 100 mg/kg PGN, orally for 35 days) and control (received 2% solution of Tween 80 as a PGN solvent, orally) groups. The mRNA levels of Era, Erb, p53, Bcl-2, and cytochrome p450 (Cyp19) as well as ovarian angiogenesis were analyzed through reverse transcription polymerase chain reaction and immunohistochemical techniques, respectively. Moreover, APOPTOSIS of follicular cells, serum estrogen and progesterone levels and mRNA damage were investigated via using terminal transferase and biotin-16-dUTP staining, electrochemilunescence and fluorescent microscopy methods, respectively. Results: The PGN reduced Era, Erb and Cyp19 expression at 50 mg/kg and 100 mg/kg doses, while significantly elevating p53 and reducing Bcl-2 expression. Finally, PGN impaired ovarian angiogenesis, increased APOPTOSIS, elevated follicular atresia and reduced serum levels of estrogen and progesterone.Conclusion: Chronic exposure to PGN (50 mg/kg and 100 mg/kg), severely affects ovarian AROMATIZATION, proto-oncogenes mRNA levels and expression of ERs.

Cites

  • No record.

    • References

    Cite

    APA: Copy

    SOULDOUZI, ROHIYEH, RAZI, MAZDAK, SHALIZAR JALALI, ALI, JALILZADEH, AMIN GHADER, & AMANI, SAEEDEH. (2018). EFFECT OF (R)-(+) PULEGONE ON OVARIAN TISSUE; CORRELATION WITH EXPRESSION OF AROMATASE CYP19 AND OVARIAN SELECTED GENES IN MICE. CELL JOURNAL (YAKHTEH), 20(2), 231-243. SID. https://sid.ir/paper/714153/en

    Vancouver: Copy

    SOULDOUZI ROHIYEH, RAZI MAZDAK, SHALIZAR JALALI ALI, JALILZADEH AMIN GHADER, AMANI SAEEDEH. EFFECT OF (R)-(+) PULEGONE ON OVARIAN TISSUE; CORRELATION WITH EXPRESSION OF AROMATASE CYP19 AND OVARIAN SELECTED GENES IN MICE. CELL JOURNAL (YAKHTEH)[Internet]. 2018;20(2):231-243. Available from: https://sid.ir/paper/714153/en

    IEEE: Copy

    ROHIYEH SOULDOUZI, MAZDAK RAZI, ALI SHALIZAR JALALI, AMIN GHADER JALILZADEH, and SAEEDEH AMANI, “EFFECT OF (R)-(+) PULEGONE ON OVARIAN TISSUE; CORRELATION WITH EXPRESSION OF AROMATASE CYP19 AND OVARIAN SELECTED GENES IN MICE,” CELL JOURNAL (YAKHTEH), vol. 20, no. 2, pp. 231–243, 2018, [Online]. Available: https://sid.ir/paper/714153/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top
    telegram sharing button
    whatsapp sharing button
    linkedin sharing button
    twitter sharing button
    email sharing button
    email sharing button
    email sharing button
    sharethis sharing button