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Information Journal Paper

Title

Polymorphisms at activated protein C cleavage sites of factor V: Are they important in the absence of factor V Leiden?

Pages

  30-33

Abstract

 Background: Activated protein C (APC) inactivates Factor V (FV) by cleavage of its heavy chain at Arg306, Arg506, Arg679, and Lys994. Mutational changes, which abolish APC Cleavage Sites, may predispose thrombosis by altering the inactivation process of FV. FV Leiden (FVL) (Arg506Glu) has been demonstrated as a strong risk factor for thrombosis. In the current study, we have studied whether mutations in the Cleavage Sites of FV for APC, not due to FVL, would have a role in presenting APC resistance (APCR) and initiation of a cerebral thrombotic event. Methods: A group of 22 patients with a history of Cerebral Venous Thrombosis (CVT), who were not carriers of FVL enrolled in the study. The patients who had conditions associated with acquired APCR were excluded from the study. APCR test was performed on the remaining 16 patients, which showed APCR in 4 plasma samples. DNA sequencing was performed on four exons of FV of APCR patients, encoding Arg306, Arg506, Arg679, and Lys994. Results: Mutations were not found within nucleotides encoding the Cleavage Sites; neither was found within their close upstream and downstream sequences. Conclusion: Our results show that polymorphisms affecting Cleavage Sites of FV other than Arg506Glu it would be less likely to be the basis for APCR and its increased thrombosis susceptibility. In addition, it emphasizes on the importance of screening for APCR in the patients diagnosed with CVT.

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    APA: Copy

    KHERADMAND, EHSAN, HAGHJOOY JAVANMARD, SHAGHAYEGH, DEHGHANI, LEILA, & SAADATNIA, MOHAMMAD. (2017). Polymorphisms at activated protein C cleavage sites of factor V: Are they important in the absence of factor V Leiden?. CURRENT JOURNAL OF NEUROLOGY (IRANIAN JOURNAL OF NEUROLOGY), 16(1), 30-33. SID. https://sid.ir/paper/717656/en

    Vancouver: Copy

    KHERADMAND EHSAN, HAGHJOOY JAVANMARD SHAGHAYEGH, DEHGHANI LEILA, SAADATNIA MOHAMMAD. Polymorphisms at activated protein C cleavage sites of factor V: Are they important in the absence of factor V Leiden?. CURRENT JOURNAL OF NEUROLOGY (IRANIAN JOURNAL OF NEUROLOGY)[Internet]. 2017;16(1):30-33. Available from: https://sid.ir/paper/717656/en

    IEEE: Copy

    EHSAN KHERADMAND, SHAGHAYEGH HAGHJOOY JAVANMARD, LEILA DEHGHANI, and MOHAMMAD SAADATNIA, “Polymorphisms at activated protein C cleavage sites of factor V: Are they important in the absence of factor V Leiden?,” CURRENT JOURNAL OF NEUROLOGY (IRANIAN JOURNAL OF NEUROLOGY), vol. 16, no. 1, pp. 30–33, 2017, [Online]. Available: https://sid.ir/paper/717656/en

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