Spectroscopic and Molecular Docking Studies on DNA Binding Interaction of Podophyllotoxin

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Heidary Alizadeh B.; DEHGHAN GH.; Derakhsh Ahmadi V.; MOGHIMI S.; ASADIPOUR A.; FOROUMADI A.

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Journal Paper

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Journal: Journal of Sciences, Islamic Republic of Iran Year:2018 | Volume:29 | Issue:2 Page(s): 121-127

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Title

Spectroscopic and Molecular Docking Studies on DNA Binding Interaction of Podophyllotoxin

Author(s)

Keywords

Spectroscopy

Podophyllotoxin

DNA

Ccompetitive fluorescence

Groove binding

Abstract

The binding interaction of novel Podophyllotoxin derivative, (3R, 4R)-4-((benzo[d][1, 3]dioxol-5-yl)methyl)-dihydro-3-(hydroxy(3, 4-dimethoxyphenyl) methyl) furan-2(3H)-one (PPT), with calf thymus DNA (ctDNA) has been examined using UVVisible absorption spectrophotometry, fluorescence Spectroscopy, viscosity measurement and molecular docking studies. UV-Vis absorption results showed hyperchromic effect and low binding constant value (1. 01×104 M-1), indicating nonintercalative interaction as a binding mode. The competitive fluorescence study also confirmed the obtained results from UV-Vis absorption spectra. Small changes in the viscosity of DNA exhibited that the interaction of PPT with DNA is based on Groove binding mode. Molecular docking study showed minor groove interaction and-7. 08 kcal/mol as a calculated energy.

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APA: Copy

Heidary Alizadeh, B., DEHGHAN, GH., Derakhsh Ahmadi, V., MOGHIMI, S., & ASADIPOUR, A.. (2018). Spectroscopic and Molecular Docking Studies on DNA Binding Interaction of Podophyllotoxin. JOURNAL OF SCIENCES ISLAMIC REPUBLIC OF IRAN, 29(2), 121-127. SID. https://sid.ir/paper/718631/en

Vancouver: Copy

Heidary Alizadeh B., DEHGHAN GH., Derakhsh Ahmadi V., MOGHIMI S., ASADIPOUR A.. Spectroscopic and Molecular Docking Studies on DNA Binding Interaction of Podophyllotoxin. JOURNAL OF SCIENCES ISLAMIC REPUBLIC OF IRAN[Internet]. 2018;29(2):121-127. Available from: https://sid.ir/paper/718631/en

IEEE: Copy

B. Heidary Alizadeh, GH. DEHGHAN, V. Derakhsh Ahmadi, S. MOGHIMI, and A. ASADIPOUR, “Spectroscopic and Molecular Docking Studies on DNA Binding Interaction of Podophyllotoxin,” JOURNAL OF SCIENCES ISLAMIC REPUBLIC OF IRAN, vol. 29, no. 2, pp. 121–127, 2018, [Online]. Available: https://sid.ir/paper/718631/en

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