Status of Bone Mineral Density in Children with Type 1 Diabetes Mellitus and Its Related Factors

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SAYARIFARD FATEMEH; Safarirad Molood; RABBANI ALI; SAYARIFARD AZADEH; ZIAEE VAHID; SETOODEH ARIA; ROSTAMI PARASTOO

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Journal: Iranian Journal of Pediatrics Year:2017 | Volume:27 | Issue:4 Page(s): 0-0

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Title

Status of Bone Mineral Density in Children with Type 1 Diabetes Mellitus and Its Related Factors

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Keywords

Type 1 Diabetes mellitus

Bone Mineral Density

Children

Abstract

Background: Type 1 Diabetes mellitus (DM) causes changes in Bone Mineral Density (BMD). Objectives: The aim of this study was to evaluateBMDin Children with type 1DMand predictive factors of BMDloss in these patients. Methods: This cross-sectional study was conducted on 112 Children with type 1 DM referrtd to Children’ s medical center in Tehran, Iran during 2015 and 2016. Serum levels of hemoglobin A1c (HbA1c), Insulin-like growth factor 1 (IGF-1), 25-hydroxy vitaminD(25(OH) D), calcium, phosphorus, parathyroid hormone (PTH), alkaline phosphates (ALP), Fasting blood sugar (FBS) was recorded. Lumbar spinal BMD (L1-L4) was measured in all patients by dual energy X-ray absorptiometry (DEXA). A BMD Z-score of -1 was accepted as normal; between-1 and-2, in the low range of normality; and -2, low BMD. Bone mineral content (BMC) was calculated by DEXA and recorded. Results: Median age was 12. 5 (4-14) years. LowBMDandBMDin the low range of normality were diagnosed in 17 (15. 2%) and 25 (22. 3%) of patients, respectively. There was a significant correlation between BMD and patient age (P < 0. 001), age of onset of diabetes (P < 0. 001), IGF-1 (P = 0. 002), HbA1c (P = 0. 001) and PTH (P = 0. 040) but only HbA1c increased level significantly predicted reduction of BMD. Conclusions: Glycemic control in Children with type I diabetes is mainly predictor of changes inBMDand the changes inBMDwere observed mainly in older ages and is independent of gender.

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APA: Copy

SAYARIFARD, FATEMEH, Safarirad, Molood, RABBANI, ALI, SAYARIFARD, AZADEH, SETOODEH, ARIA, & ROSTAMI, PARASTOO. (2017). Status of Bone Mineral Density in Children with Type 1 Diabetes Mellitus and Its Related Factors. IRANIAN JOURNAL OF PEDIATRICS, 27(4), 0-0. SID. https://sid.ir/paper/719929/en

Vancouver: Copy

SAYARIFARD FATEMEH, Safarirad Molood, RABBANI ALI, SAYARIFARD AZADEH, SETOODEH ARIA, ROSTAMI PARASTOO. Status of Bone Mineral Density in Children with Type 1 Diabetes Mellitus and Its Related Factors. IRANIAN JOURNAL OF PEDIATRICS[Internet]. 2017;27(4):0-0. Available from: https://sid.ir/paper/719929/en

IEEE: Copy

FATEMEH SAYARIFARD, Molood Safarirad, ALI RABBANI, AZADEH SAYARIFARD, ARIA SETOODEH, and PARASTOO ROSTAMI, “Status of Bone Mineral Density in Children with Type 1 Diabetes Mellitus and Its Related Factors,” IRANIAN JOURNAL OF PEDIATRICS, vol. 27, no. 4, pp. 0–0, 2017, [Online]. Available: https://sid.ir/paper/719929/en

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