THE IMPACT OF GENETIC VARIATION AND GENE EXPRESSION LEVEL OF THE FOLLICLE-STIMULATING HORMONE RECEPTOR ON OVARIAN RESERVE

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GHEZELAYAGH ZEINAB; TOTONCHI MEHDI; ZAREI MORADI SHABNAM; ASADPOUR OMMOLBANIN; MAROUFIZADEH SAMAN; EFTEKHARI YAZDI POOPAK; GOURABI HAMID; MOHSENI MEYBODI ANAHITA

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Journal: Cell Journal (Yakhteh) Year:2018 | Volume:19 | Issue:4 Page(s): 620-626

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Title

THE IMPACT OF GENETIC VARIATION AND GENE EXPRESSION LEVEL OF THE FOLLICLE-STIMULATING HORMONE RECEPTOR ON OVARIAN RESERVE

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Keywords

ALLELIC VARIANTS

FOLLICLE STIMULATING HORMONE RECEPTOR

PREMATURE OVARIAN FAILURE

Abstract

Objective: Ovarian reserve is defined as the capacity of the ovary to provide fertile oocytes. Diminished ovarian reserve (DOR) is a disorder in which ovaries are prone to go through early menopause. Where this loss of function occurs before the age of 40, it results in the PREMATURE OVARIAN FAILURE (POF) disease. Throughout folliculogenesis, the follicle-stimulating hormone receptor (FSHR) starts a signaling cascade in the granulosa cells where its inactivation leads to the arrest of follicle maturation and therefore adversely affects ovarian reserve. The aim of this study was to investigate the association of genetic variation (polymorphisms and inactivating mutations) ofFSHR with POF and DOR.Materials and Methods: This case-control study comprised 84 POF, 52 DOR and 80 fertile Iranian women. To determine the presence of the 566C>T mutation and the -29G>A polymorphism inFSHR, PCR-RFLP method was used. SSCP-sequencing was used to identify any ALLELIC VARIANTS in exon 10. The expression of humanFSHR at the transcript level was also compared between DOR and fertile controls by real time-polymerase chain reaction (PCR).Results: The 566C>T polymorphism was normal in all the cases. All genotypes of -29G>A and 919G>A (exon 10) polymorphisms were observed. Statistically significant differences were seen in the genotypic distribution of both polymorphisms when comparing the control group with the DOR patient group. A decrease was observed inFSHR expression of DOR patients compared with the control group but was not significant.Conclusion: We conclude that the -29G>A and 919G>A polymorphisms in FSHR may be associated with DOR. Although these polymorphisms had significant differences at the genic level, no significant variation was found at the transcript level

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APA: Copy

GHEZELAYAGH, ZEINAB, TOTONCHI, MEHDI, ZAREI MORADI, SHABNAM, ASADPOUR, OMMOLBANIN, MAROUFIZADEH, SAMAN, EFTEKHARI YAZDI, POOPAK, GOURABI, HAMID, & MOHSENI MEYBODI, ANAHITA. (2018). THE IMPACT OF GENETIC VARIATION AND GENE EXPRESSION LEVEL OF THE FOLLICLE-STIMULATING HORMONE RECEPTOR ON OVARIAN RESERVE. CELL JOURNAL (YAKHTEH), 19(4), 620-626. SID. https://sid.ir/paper/720450/en

Vancouver: Copy

GHEZELAYAGH ZEINAB, TOTONCHI MEHDI, ZAREI MORADI SHABNAM, ASADPOUR OMMOLBANIN, MAROUFIZADEH SAMAN, EFTEKHARI YAZDI POOPAK, GOURABI HAMID, MOHSENI MEYBODI ANAHITA. THE IMPACT OF GENETIC VARIATION AND GENE EXPRESSION LEVEL OF THE FOLLICLE-STIMULATING HORMONE RECEPTOR ON OVARIAN RESERVE. CELL JOURNAL (YAKHTEH)[Internet]. 2018;19(4):620-626. Available from: https://sid.ir/paper/720450/en

IEEE: Copy

ZEINAB GHEZELAYAGH, MEHDI TOTONCHI, SHABNAM ZAREI MORADI, OMMOLBANIN ASADPOUR, SAMAN MAROUFIZADEH, POOPAK EFTEKHARI YAZDI, HAMID GOURABI, and ANAHITA MOHSENI MEYBODI, “THE IMPACT OF GENETIC VARIATION AND GENE EXPRESSION LEVEL OF THE FOLLICLE-STIMULATING HORMONE RECEPTOR ON OVARIAN RESERVE,” CELL JOURNAL (YAKHTEH), vol. 19, no. 4, pp. 620–626, 2018, [Online]. Available: https://sid.ir/paper/720450/en

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