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Information Journal Paper

Title

Di-(2-ethylhexyl) phthalate induces precocious puberty in adolescent female rats

Pages

  848-855

Keywords

Di-(2-ethylhexyl) phthalate 

Abstract

 Objective(s): Nowadays, Di-(2-ethylhexyl) phthalate (DEHP) is widely used in different kinds of commercial products as a plasticizer. Previous studies have revealed that exposures to DEHP could be associated with Precocious puberty in teenagers, but the exact mechanism is yet to be known. Materials and Methods: In this study, 48 prepubertal Wistar Female rats were randomly apportioned into 4 groups and orally treated with 0, 250, 500, and 1000 mg/kg/d DEHP from postnatal day 21 up to 4 weeks. Subsequently, we examined the indicators related to the initiation of sexual development. Results: DEHP was able to shorten the vaginal opening time and prolong the estrous cycles of Female rats. IGF-1 expression was significantly upregulated by 1000 mg/kg/d DEHP in the Hypothalamus, and the hypothalamic, as well as serum levels of GH, were also upregulated by DEHP. It also caused decrements in serum levels of FSH, LH, and T and the increment in level of progesterone. Meanwhile, DEHP was able to exert its effect on the mRNA and protein expression levels of Kiss-1, GPR54, and GnRH in the Hypothalamus in pubertal Female rats. Conclusion: These findings are revealing that DEHP exposure more likely causes imbalances of Hypothalamus functioning in pubertal Female rats and thus induces precautious puberty in these animals.

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    Cite

    APA: Copy

    Liu, te, Wang, Yuzhuo, Yang, Modi, Shao, Pu, Duan, Lian, Li, Meng, Zhu, Mingji, YANG, JIE, & Jiang, Jinlan. (2018). Di-(2-ethylhexyl) phthalate induces precocious puberty in adolescent female rats. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 21(8), 848-855. SID. https://sid.ir/paper/721365/en

    Vancouver: Copy

    Liu te, Wang Yuzhuo, Yang Modi, Shao Pu, Duan Lian, Li Meng, Zhu Mingji, YANG JIE, Jiang Jinlan. Di-(2-ethylhexyl) phthalate induces precocious puberty in adolescent female rats. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2018;21(8):848-855. Available from: https://sid.ir/paper/721365/en

    IEEE: Copy

    te Liu, Yuzhuo Wang, Modi Yang, Pu Shao, Lian Duan, Meng Li, Mingji Zhu, JIE YANG, and Jinlan Jiang, “Di-(2-ethylhexyl) phthalate induces precocious puberty in adolescent female rats,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 21, no. 8, pp. 848–855, 2018, [Online]. Available: https://sid.ir/paper/721365/en

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