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Information Journal Paper

Title

Preparation and evaluation of PCL-PEG-PCL micelles as potential nanocarriers for ocular delivery of dexamethasone

Pages

  153-164

Abstract

 Objective(s): Micelles have been studied as nanoparticulate drug delivery systems for improving the topical ocular delivery of hydrophobic drugs. The objective of this study was to develop and characterize Dexamethasone-loaded polycaprolactone-polyethylene glycol-polycaprolactone (PCL-PEG-PCL) Micelles to improve patient compliance and enhance the ocular bioavailability of poorly water-soluble drugs. Materials and Methods: The PCL-PEG-PCL copolymers were synthesized via the ring opening polymerization of ε-caprolactone in the presence of PEG. The resulting purified copolymers were characterized by GPC, NMR, FTIR, XRD and DSC. The Micelle concentration/fa?page=1&sort=1&ftyp=all&fgrp=all&fyrs=all" target="_blank">Critical Micelle concentrations (CMCs) of the mentioned copolymers were determined. Dexamethasone was loaded into polymeric Micelles by film hydration method, and Dexamethasone-loaded Micelles were characterized by TEM and DLS. Drug release kinetics and ex vivo corneal permeability were also determined. Results: The CMC of the synthetized copolymers was approximately 0. 03 mg/ml. Aqueous solutions of the resulting copolymers (400 mg/ml) rapidly formed a gel in situ at 34° C. The TEM results exhibited the successful formation of spherical Micelles. The size of the prepared Micelles was approximately 40 nm. Formulated Micelles sustained the release of the incorporated Dexamethasone for 5 days. Conclusion: Data from ex vivo permeability tests indicated that PCL-PEG-PCL Micelles can be suitable candidates for the ocular delivery of Dexamethasone and, likely, other hydrophobic drugs.

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    APA: Copy

    Alami Milani, Mitra, ZAKERI MILANI, PARVIN, VALIZADEH, HADI, salehi, Roya, & JELVEHGARI, MITRA. (2018). Preparation and evaluation of PCL-PEG-PCL micelles as potential nanocarriers for ocular delivery of dexamethasone. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 21(2), 153-164. SID. https://sid.ir/paper/721874/en

    Vancouver: Copy

    Alami Milani Mitra, ZAKERI MILANI PARVIN, VALIZADEH HADI, salehi Roya, JELVEHGARI MITRA. Preparation and evaluation of PCL-PEG-PCL micelles as potential nanocarriers for ocular delivery of dexamethasone. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2018;21(2):153-164. Available from: https://sid.ir/paper/721874/en

    IEEE: Copy

    Mitra Alami Milani, PARVIN ZAKERI MILANI, HADI VALIZADEH, Roya salehi, and MITRA JELVEHGARI, “Preparation and evaluation of PCL-PEG-PCL micelles as potential nanocarriers for ocular delivery of dexamethasone,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 21, no. 2, pp. 153–164, 2018, [Online]. Available: https://sid.ir/paper/721874/en

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