Association of lipid markers with coronary heart disease and stroke mortality: A 15-year follow-up study

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PAHLAVANZADEH BAGHER; ZAYERI FARID; Baghfalaki Taban; MOZAFARI OMID; KHALILI DAVOOD; AZIZI FEREIDOUN; ABADI ALIREZA

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Journal Paper

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Journal: Iranian Journal of Basic Medical Sciences Year:2019 | Volume:22 | Issue:11 Page(s): 1325-1330

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Title

Association of lipid markers with coronary heart disease and stroke mortality: A 15-year follow-up study

Author(s)

Keywords

Coronary heart disease

Cholesterol HDL

Cholesterol LDL

Stroke

Survival analysis

Abstract

Objective(s): It has been proposed that lipid markers may predict cardiovascular events; however, their effect may vary depending on the type of cardiovascular disease. The purpose of this study was to investigate the effects of lipid markers on death from Coronary heart disease (CHD) and Stroke in competing risks setting. Materials and Methods: Participants included 2502 women and 2020 men, age 40 years or older from Tehran Lipid and Glucose Study. The association between total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), triglyceride (TG), and high-density lipoprotein cholesterol (HDL-C) with hazard and cumulative incidence of CHD and Stroke was investigated using cause-specific hazard and sub-distribution hazard models. Statistical analyses were performed using “ risk regression” and “ cmprsk” package in R 3. 3. 2. Results: One standard deviation (SD) increase in TC and LDL-C increased the hazard of CHD death by 1. 42 (CI=1. 07, 1. 89) and 1. 41 (CI=1. 04, 1. 93), respectively. 1-SD increase in TG increased the cumulative incidence of CHD death increased by 1. 94 (CI=1. 02, 3. 75) in women. Other risk factors were not associated with the hazard and cumulative incidence of CHD in women, men and the total sample. In addition, none of lipids had a significant effect on the hazard and cumulative incidence of Stroke in men, women and the total sample. Conclusion: The associations of lipid components on CHD death were modified by gender. TC, LDL-C and TG were independent predictors of CHD mortality in women. Furthermore, death due to Stroke changes the association of lipid markers with CHD mortality.

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APA: Copy

PAHLAVANZADEH, BAGHER, ZAYERI, FARID, Baghfalaki, Taban, MOZAFARI, OMID, KHALILI, DAVOOD, AZIZI, FEREIDOUN, & ABADI, ALIREZA. (2019). Association of lipid markers with coronary heart disease and stroke mortality: A 15-year follow-up study. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 22(11), 1325-1330. SID. https://sid.ir/paper/722543/en

Vancouver: Copy

PAHLAVANZADEH BAGHER, ZAYERI FARID, Baghfalaki Taban, MOZAFARI OMID, KHALILI DAVOOD, AZIZI FEREIDOUN, ABADI ALIREZA. Association of lipid markers with coronary heart disease and stroke mortality: A 15-year follow-up study. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2019;22(11):1325-1330. Available from: https://sid.ir/paper/722543/en

IEEE: Copy

BAGHER PAHLAVANZADEH, FARID ZAYERI, Taban Baghfalaki, OMID MOZAFARI, DAVOOD KHALILI, FEREIDOUN AZIZI, and ALIREZA ABADI, “Association of lipid markers with coronary heart disease and stroke mortality: A 15-year follow-up study,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 22, no. 11, pp. 1325–1330, 2019, [Online]. Available: https://sid.ir/paper/722543/en

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