Protective effect of metformin on D-galactose-induced aging model in mice

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FATEMI IMAN; Khaluoi Amin; KAEIDI AYAT; SHAMSIZADEH ALI; HEYDARI SARA; ALLAHTAVAKOLI MOHAMMAD

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Journal: Iranian Journal of Basic Medical Sciences Year:2018 | Volume:21 | Issue:1 Page(s): 19-25

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Title

Protective effect of metformin on D-galactose-induced aging model in mice

Author(s)

Keywords

Aging

D-galactose

Metformin

Mouse

Oxidative stress

Abstract

Objective(s): Metformin (Met), an antidiabetic biguanide, reduces hyperglycemia via improving glucose utilization and reducing the gluconeogenesis. Met has been shown to exert neuroprotective, antioxidant and anti-inflammatory properties. The present study investigated the possible effect of Met on the D-galactose (D-gal)-induced Aging in mice. Materials and Methods: Met (1 and 10 mg/kg/p. o. ), was administrated daily in D-gal-received (500 mg/kg/p. o. ) mice model of Aging for six weeks. Anxiety-like behavior, cognitive function, and physical power were evaluated by the elevated plus-maze, novel object recognition task (NORT), and forced swimming capacity test, respectively. The brains were analyzed for the level of superoxide dismutase (SOD) and brain-derived neurotrophic factor (BDNF). Results: Met decreased the anxiety-like behavior in D-gal-treated mice. Also, Met treated mice showed significantly improved learning and memory ability in NORT compared to the D-gal-treated mice. Furthermore, Met increased the physical power as well as the activity of SOD and BDNF level in D-gal-treated mice. Conclusion: Our results suggest that the use of Met can be an effective strategy for prevention and treatment of D-gal-induced Aging in animal models. This effect seems to be mediated by attenuation of Oxidative stress and enhancement of the neurotrophic factors.

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APA: Copy

FATEMI, IMAN, Khaluoi, Amin, KAEIDI, AYAT, SHAMSIZADEH, ALI, HEYDARI, SARA, & ALLAHTAVAKOLI, MOHAMMAD. (2018). Protective effect of metformin on D-galactose-induced aging model in mice. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 21(1), 19-25. SID. https://sid.ir/paper/722791/en

Vancouver: Copy

FATEMI IMAN, Khaluoi Amin, KAEIDI AYAT, SHAMSIZADEH ALI, HEYDARI SARA, ALLAHTAVAKOLI MOHAMMAD. Protective effect of metformin on D-galactose-induced aging model in mice. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2018;21(1):19-25. Available from: https://sid.ir/paper/722791/en

IEEE: Copy

IMAN FATEMI, Amin Khaluoi, AYAT KAEIDI, ALI SHAMSIZADEH, SARA HEYDARI, and MOHAMMAD ALLAHTAVAKOLI, “Protective effect of metformin on D-galactose-induced aging model in mice,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 21, no. 1, pp. 19–25, 2018, [Online]. Available: https://sid.ir/paper/722791/en

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