Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

238
Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

102
Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

Information Journal Paper

Title

Expression Analysis of the CRISP2, CATSPER1, PATE1 and SEMG1 in the Sperm of Men with Idiopathic Asthenozoospermia

Pages

  70-75

Abstract

 Background: The purpose of this study was to analyze the expression level of CRISP2, CATSPER1, PATE1 and SEMG1 genes in the sperm of men with astheno-zoospermia (AZS). AZS is a cause of infertility in men in which the motility of the sperm is reduced. So far, a few genes have been associated with AZS; however, in most of the cases, its molecular etiology is unclear. Methods: A total of 35 subjects with idiopathic AZS and 35 fertile and healthy men as control were included. In study after total RNA extraction and cDNA synthesis, relative quantification was performed. B2M was used as the normalizer gene and fold change was calculated by 2− Δ Δ Ctmethod. Mann-Whitney test was used to com-pare the expression levels between the case and control groups with significance lev-el of p<0. 05. Results: Our results showed that CRISP2 (p=0. 03) and SEMG1 (p=0. 03) were sig-nificantly down-and up-regulated in AZS men respectively compared to the con-trols. But CATSPER1 and PATE1 did not show significant changes. Conclusion: Down-regulation of CRISP2 and up-regulation of SEMG1 were associ-ated with AZS, which could be suggested as the potential candidate genes for the de-velopment of a diagnostic marker or potentially for more studies for treatment of AZS.

Cites

  • No record.

    • References

    Cite

    APA: Copy

    HEIDARY, ZOHREH, Zaki dizaji, Majid, SALIMINEJAD, KIOOMARS, & KHORRAMKHORSHID, HAMID REZA. (2019). Expression Analysis of the CRISP2, CATSPER1, PATE1 and SEMG1 in the Sperm of Men with Idiopathic Asthenozoospermia. JOURNAL OF REPRODUCTION AND INFERTILITY, 20(2), 70-75. SID. https://sid.ir/paper/724990/en

    Vancouver: Copy

    HEIDARY ZOHREH, Zaki dizaji Majid, SALIMINEJAD KIOOMARS, KHORRAMKHORSHID HAMID REZA. Expression Analysis of the CRISP2, CATSPER1, PATE1 and SEMG1 in the Sperm of Men with Idiopathic Asthenozoospermia. JOURNAL OF REPRODUCTION AND INFERTILITY[Internet]. 2019;20(2):70-75. Available from: https://sid.ir/paper/724990/en

    IEEE: Copy

    ZOHREH HEIDARY, Majid Zaki dizaji, KIOOMARS SALIMINEJAD, and HAMID REZA KHORRAMKHORSHID, “Expression Analysis of the CRISP2, CATSPER1, PATE1 and SEMG1 in the Sperm of Men with Idiopathic Asthenozoospermia,” JOURNAL OF REPRODUCTION AND INFERTILITY, vol. 20, no. 2, pp. 70–75, 2019, [Online]. Available: https://sid.ir/paper/724990/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top