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Information Journal Paper

Title

The effects of fenvalerate on hepatic and cerebral xenobiotic metabolizing enzymes in selenium and/or iodine deficient rats

Pages

  1040-1048

Abstract

 Objective(s): Particularly in developing countries, Selenium and/or Iodine deficiencies are encountered and use of pesticides in agriculture are not well-controlled. Fenvalerate is a pyrethroid insectide used in agriculture and has applications against a wide range of pests. This study was designed to evaluate the effects of Fenvalerate on hepatic and cerebral xenobiotic metabolizing enzyme activities in the presence of Iodine and/or Selenium deficiency on a rat model. Materials and Methods: Iodine and/or Selenium deficiency was induced by feeding three-week-old Wistar rats with a diet containing <0. 005 mg Selenium kg-1, and/or administering 1% sodium perchlorate in drinking water for 7 weeks. Test groups received Fenvalerate (100 mg kg-1 BW IP) for the last 7 days. Hepatic and cerebral microsomal aniline hydroxylase (CYP2E1) and cytosolic glutathione S-transferase (GST) activities were determined. Besides, hepatic NADPH-cytochrome P450 reductase (P450R), ethoxyresorufin O-deethylase (EROD, CYP1A1/1A2) and penthoxyresorufin O-depenthylase (PROD, CYP2B1/2B2), activities were also measured. Results: Fenvalerate had a general inductive effect on the hepatic and cerebral xenobiotic metabolizing enzyme activities. Moreover, enzyme activities were also altered by Iodine and/or Selenium deficiency, but the effects seemed to be enzyme-and tissue-specific. Conclusion: The inductive effect of Fenvalerate, particularly in high dose exposures, may change the metabolism of several xenobiotics, including drugs, as well as endogenous substrates. The effects may vary depending on the Selenium and/or Iodine status of individual.

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    • Cite

    APA: Copy

    Caglayan, Aydan, Kocer Gumusel, Belma, Erkekoglu, Pinar, & Hincal, Filiz. (2016). The effects of fenvalerate on hepatic and cerebral xenobiotic metabolizing enzymes in selenium and/or iodine deficient rats. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 19(10), 1040-1048. SID. https://sid.ir/paper/725686/en

    Vancouver: Copy

    Caglayan Aydan, Kocer Gumusel Belma, Erkekoglu Pinar, Hincal Filiz. The effects of fenvalerate on hepatic and cerebral xenobiotic metabolizing enzymes in selenium and/or iodine deficient rats. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2016;19(10):1040-1048. Available from: https://sid.ir/paper/725686/en

    IEEE: Copy

    Aydan Caglayan, Belma Kocer Gumusel, Pinar Erkekoglu, and Filiz Hincal, “The effects of fenvalerate on hepatic and cerebral xenobiotic metabolizing enzymes in selenium and/or iodine deficient rats,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 19, no. 10, pp. 1040–1048, 2016, [Online]. Available: https://sid.ir/paper/725686/en

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