Effects of troxerutin on anxiety-and depressive-like behaviors induced by chronic mild stress in adult male rats

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AZARFARIN MARYAM; Farajdokht Fereshteh; BABRI SHIRIN; Salehpour Farzad; Taghizadeh Milad; MOHADDES GISOU

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Journal: Iranian Journal of Basic Medical Sciences Year:2018 | Volume:21 | Issue:8 Page(s): 781-786

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Title

Effects of troxerutin on anxiety-and depressive-like behaviors induced by chronic mild stress in adult male rats

Author(s)

Keywords

Anxiety

Chronic mild stress

Cortisol

Depression

Troxerutin

Abstract

Objective(s): Chronic stress has been linked to the pathophysiology of mood disorders including Anxiety and Depression. In this study, we aimed to investigate the effect of Troxerutin (TRX), as a flavonol, on stress-induced Anxiety and Depression. Materials and Methods: 56 animals were randomly divided into seven groups (n=8 per group) as follows: control, saline, TRX 50, TRX 150, TRX 300, Diazepam, and Imipramine. Chronic mild stress (CMS) was induced by restraining animals in Plexiglas cylinders for 1 hr each day for 25 consecutive days. Different doses (50, 150, and 300 mg/kg, oral gavage) of Troxerutin was gavaged for 14 consecutive days. At the end of treatments, Anxiety-and depressive-like behaviors were tested using elevated plus-maze (EPM), open field test (OFT), and forced swimming test (FST). Results: CMS significantly increased immobility (P<0. 05) and decreased swimming (P<0. 01) time in FST. However, different doses of Troxerutin significantly decreased immobility (P<0. 01) and increased swimming (P<0. 001) time. CMS also significantly (P<0. 01) decreased the percentage of open arm entrance (%OAE), whereas Troxerutin significantly increased both %OAE and percentage of open arm time (%OAT) in the EPM. Moreover, CMS significantly decreased time spent in the center (P<0. 001) and the number of center entrances (P<0. 01) in the OFT. However, Troxerutin significantly increased time spent in the center and number of the entrances crossing. Furthermore, CMS significantly increased serum Cortisol levels and Troxerutin decreased it. Conclusion: Troxerutin demonstrated anxiolytic-and antidepressant-like activities in rodents, which supports the use of herbal medicine in the mood disorders.

Cites

Effect of gallic acid on chronic restraint stress-induced anxiety and memory loss in male BALB/c mice

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APA: Copy

AZARFARIN, MARYAM, Farajdokht, Fereshteh, BABRI, SHIRIN, Salehpour, Farzad, Taghizadeh, Milad, & MOHADDES, GISOU. (2018). Effects of troxerutin on anxiety-and depressive-like behaviors induced by chronic mild stress in adult male rats. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 21(8), 781-786. SID. https://sid.ir/paper/725724/en

Vancouver: Copy

AZARFARIN MARYAM, Farajdokht Fereshteh, BABRI SHIRIN, Salehpour Farzad, Taghizadeh Milad, MOHADDES GISOU. Effects of troxerutin on anxiety-and depressive-like behaviors induced by chronic mild stress in adult male rats. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2018;21(8):781-786. Available from: https://sid.ir/paper/725724/en

IEEE: Copy

MARYAM AZARFARIN, Fereshteh Farajdokht, SHIRIN BABRI, Farzad Salehpour, Milad Taghizadeh, and GISOU MOHADDES, “Effects of troxerutin on anxiety-and depressive-like behaviors induced by chronic mild stress in adult male rats,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 21, no. 8, pp. 781–786, 2018, [Online]. Available: https://sid.ir/paper/725724/en

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