Hydrogen sulfide treatment protects against renal ischemiareperfusion injury via induction of heat shock proteins in rats

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Du Yang; Liu Xiu heng; Zhu Heng cheng; WANG LEI; Wang Zhi shun; Ning Jin zhuo; Xiao Cheng cheng

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Journal: Iranian Journal of Basic Medical Sciences Year:2019 | Volume:22 | Issue:1 Page(s): 99-105

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Title

Hydrogen sulfide treatment protects against renal ischemiareperfusion injury via induction of heat shock proteins in rats

Author(s)

Keywords

Hydrogen sulfide

Heat shock protein 70

Heat shock protein 27

Heme oxygenase 1

Ischemia-reperfusion injury

Rat

Renal

Abstract

Objective(s): Hydrogen sulfide (H2S) attenuates Ischemia-reperfusion injury (IRI) in different organs. However, its mechanism of action in Renal IRI remains unclear. The present study investigated the hypothesis that H2S attenuates Renal IRI via the induction of heat shock proteins (HSPs). Materials and Methods: Adult Wistar Rats were subjected to unilateral Renal ischemia for 45 min followed by reperfusion for 6 hr. One group of Rats underwent I/R without treatment, one group was administered 150 μ mol/l sodium hydrosulfide (NaHS) prior to I/R, one group was injected with 100 mg/kg quercetin (an HSP inhibitor) intraperitoneally prior to I/R, and another group received quercetin prior to I/R and treatment with NaHS following I/R. Two other groups underwent a sham opeRation and one of them received 150 μ mol/l NaHS following the sham opeRation whereas the other received no treatment. Renal function and histological changes were compared and relevant indices of oxidative stress, apoptosis, and inflammation were examined. Results: IRI increased serum creatinine and blood urea nitrogen concentRations, promoted lipid peroxidation by elevating malondialdehyde levels, suppressed superoxide dismutase activity, stimulated inflammation by inducing NF-kB, IL-2, and TLR-4 expression, and increased Renal apoptosis. Levels of HSP 70, heme-oxygenase-1 (HO-1) and HSP 27 were increased following IRI and reversed following H2S treatment. H2S attenuated changes observed in pathology, lipid peroxidation, inflammation, and apoptosis following IRI. The administRation of quercetin reversed all protective effects of H2S. Conclusion: The present study indicated that H2S protected Renal tissue against IRI induced lipid peroxidation, inflammation, and apoptosis, which may be attributed to the upregulation of HSP 70, HO-1, and HSP 27.

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References

Luteolin protects mice from severe acute pancreatitis by exerting HO-1-mediated anti-inflammatory and antioxidant effects

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APA: Copy

Du, Yang, Liu, Xiu heng, Zhu, Heng cheng, WANG, LEI, Wang, Zhi shun, Ning, Jin zhuo, & Xiao, Cheng cheng. (2019). Hydrogen sulfide treatment protects against renal ischemiareperfusion injury via induction of heat shock proteins in rats. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 22(1), 99-105. SID. https://sid.ir/paper/726679/en

Vancouver: Copy

Du Yang, Liu Xiu heng, Zhu Heng cheng, WANG LEI, Wang Zhi shun, Ning Jin zhuo, Xiao Cheng cheng. Hydrogen sulfide treatment protects against renal ischemiareperfusion injury via induction of heat shock proteins in rats. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2019;22(1):99-105. Available from: https://sid.ir/paper/726679/en

IEEE: Copy

Yang Du, Xiu heng Liu, Heng cheng Zhu, LEI WANG, Zhi shun Wang, Jin zhuo Ning, and Cheng cheng Xiao, “Hydrogen sulfide treatment protects against renal ischemiareperfusion injury via induction of heat shock proteins in rats,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 22, no. 1, pp. 99–105, 2019, [Online]. Available: https://sid.ir/paper/726679/en

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