EFFECTS OF METHANOLIC EXTRACT OF ACHILLEA WILHELMSII C. KOCH ON SEIZURE INDUCED BY PICROTOXIN IN MICE

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HEIDARI M.R.; EBRAHIMI S.; MEHRABANI M.; PARDAKHTI A.; VAFAZADEH J.

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Journal: JOURNAL OF BABOL UNIVERSITY OF MEDICAL SCIENCES (JBUMS) Year:2005 | Volume:7 | Issue:4 (28) Page(s): 7-13

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Title

EFFECTS OF METHANOLIC EXTRACT OF ACHILLEA WILHELMSII C. KOCH ON SEIZURE INDUCED BY PICROTOXIN IN MICE

Author(s)

Keywords

ACHILLEA WILHELMSIIQ2

SEIZUREQ3

PICROTOXINQ4

Abstract

BACKGROUND AND OBJECTIVE: some therapeutic effects of medicinal plants such as Achillea have been known for many years ago. In this investigation, the effects of methanolic extract of ACHILLEA WILHELMSII C. Koch on SEIZURE induced by PICROTOXIN were studied in mice.METHODS: This study was performed on animals pretreated with different experimental doses of percolated extract of ACHILLEA WILHELMSII via intraperitoneal injection and 20 minutes after extract injections, each animal received PICROTOXIN 10 mg/kg for induction of generalized tonic and clonic SEIZURE. Latency of onset and duration of SEIZURE, death time and percent of mortality were determined.FINDINGS: The results showed that pretreatment of animals with different doses of extracts did not change the beginning time of SEIZURE induced by PICROTOXIN. The duration of SEIZURE increased (p<0.01), but the severity of SEIZUREs was milder than control group. In addition, all doses of extract lengthened the time of death (p<0.01). The mortality rate was decreased with dose of 50 and 100 mg/kg (p<0.05, p<0.01, respectively).CONCLUSIONT: The results showed that the dose of 100 mg/kg is the most effective one. The extract of ACHILLEA WILHELMSII decreased the severity of generalized tonic and clonic SEIZURE induced by PICROTOXIN and lengthened the death time; therefore it is a suitable for continuing investigation as anticonvulsant drug.

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References

EFFECTS OF VALERIANA OFFICINAL IS EXTRACT ON THE SEIZURE INDUCED BY PICROTOXIN IN MICE

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APA: Copy

HEIDARI, M.R., EBRAHIMI, S., MEHRABANI, M., PARDAKHTI, A., & VAFAZADEH, J.. (2005). EFFECTS OF METHANOLIC EXTRACT OF ACHILLEA WILHELMSII C. KOCH ON SEIZURE INDUCED BY PICROTOXIN IN MICE. JOURNAL OF BABOL UNIVERSITY OF MEDICAL SCIENCES (JBUMS), 7(4 (28)), 7-13. SID. https://sid.ir/paper/73157/en

Vancouver: Copy

HEIDARI M.R., EBRAHIMI S., MEHRABANI M., PARDAKHTI A., VAFAZADEH J.. EFFECTS OF METHANOLIC EXTRACT OF ACHILLEA WILHELMSII C. KOCH ON SEIZURE INDUCED BY PICROTOXIN IN MICE. JOURNAL OF BABOL UNIVERSITY OF MEDICAL SCIENCES (JBUMS)[Internet]. 2005;7(4 (28)):7-13. Available from: https://sid.ir/paper/73157/en

IEEE: Copy

M.R. HEIDARI, S. EBRAHIMI, M. MEHRABANI, A. PARDAKHTI, and J. VAFAZADEH, “EFFECTS OF METHANOLIC EXTRACT OF ACHILLEA WILHELMSII C. KOCH ON SEIZURE INDUCED BY PICROTOXIN IN MICE,” JOURNAL OF BABOL UNIVERSITY OF MEDICAL SCIENCES (JBUMS), vol. 7, no. 4 (28), pp. 7–13, 2005, [Online]. Available: https://sid.ir/paper/73157/en

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