EFFECT OF FORMALDEHYDE ON INTERSTITIAL TISSUE OF SEMINIFEROUS TUBULES IN TESTIS OF BALB/C MICE

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NIKRAVESH M.R.; JALALI MAHDI; FAZEL A.R.

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Journal: JOURNAL OF BABOL UNIVERSITY OF MEDICAL SCIENCES (JBUMS) Year:2009 | Volume:10 | Issue:6 (47) Page(s): 23-30

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Title

EFFECT OF FORMALDEHYDE ON INTERSTITIAL TISSUE OF SEMINIFEROUS TUBULES IN TESTIS OF BALB/C MICE

Author(s)

NIKRAVESH M.R. | JALALI MAHDI | FAZEL A.R. | Issue Writer Certificate

Keywords

FORMALDEHYDEQ3

IMMUNOHISTOCHEMISTRY. TESTIS INTERSTITIAL TISSUEQ3

MOUSSEQ3

Abstract

BACKGROUND AND OBJECTIVE: FORMALDEHYDE is one of agents with absorbable potential which can use in industry and also in many productions such as technical, pharmaceutical and sanitary compounds. Previous study shown that FORMALDEHYDE can affect on testicular tissue and reduce spennatogenesis phenomena. This study was carried out to determine the effects of FORMALDEHYDE on leydig cells and testicular vasculogenesis.METHODS: Twenty mature male Balb/c mice were randomly divided into experimental and control groups (n=10). Experimental group were administered 0.25mg/kg body weight dissolved FORMALDEHYDE intraperitoneally for 10 days. The control groups were received the same volume of normal saline during the same period of times. At the end of exposure time, animals were scarified and their testes were removed for processing, serially sectioned and immunohistochemistry by using PCNA method, were carried out.FINDINGS: The finding revealed that the numerical density of leydig cells decreased significantly in experimental group in contrast controls (42 versus 66 per/m3 respectively). In addition, a number of shrinkage and picnotic leydig cells indicated occurrence of chromatolysis phenomena in experimental group.CONCLUSION: These data reveal that administration of FORMALDEHYDE may result in significant structural changes in male reproductive system such as interstitial tissue of seminiferous tubules and cell death among leydig cells population.

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APA: Copy

NIKRAVESH, M.R., JALALI, MAHDI, & FAZEL, A.R.. (2009). EFFECT OF FORMALDEHYDE ON INTERSTITIAL TISSUE OF SEMINIFEROUS TUBULES IN TESTIS OF BALB/C MICE. JOURNAL OF BABOL UNIVERSITY OF MEDICAL SCIENCES (JBUMS), 10(6 (47)), 23-30. SID. https://sid.ir/paper/73222/en

Vancouver: Copy

NIKRAVESH M.R., JALALI MAHDI, FAZEL A.R.. EFFECT OF FORMALDEHYDE ON INTERSTITIAL TISSUE OF SEMINIFEROUS TUBULES IN TESTIS OF BALB/C MICE. JOURNAL OF BABOL UNIVERSITY OF MEDICAL SCIENCES (JBUMS)[Internet]. 2009;10(6 (47)):23-30. Available from: https://sid.ir/paper/73222/en

IEEE: Copy

M.R. NIKRAVESH, MAHDI JALALI, and A.R. FAZEL, “EFFECT OF FORMALDEHYDE ON INTERSTITIAL TISSUE OF SEMINIFEROUS TUBULES IN TESTIS OF BALB/C MICE,” JOURNAL OF BABOL UNIVERSITY OF MEDICAL SCIENCES (JBUMS), vol. 10, no. 6 (47), pp. 23–30, 2009, [Online]. Available: https://sid.ir/paper/73222/en

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