THERAPEUTIC POTENTIAL OF CORD BLOOD STEM CELL IN BRAIN DAMAGE OF AN ANIMAL MODEL

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

NIKRAVESH M.R.; GHAFFARIPOUR H.A.; JALALI M.; HAMIDI ALAMDARI D.; SANCHOOLI J.; SEGHATOLESLAM M.

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: JOURNAL OF BABOL UNIVERSITY OF MEDICAL SCIENCES (JBUMS) Year:2012 | Volume:14 | Issue:4 (67) Page(s): 22-29

Download Full-Text

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Verion

View:

1,542

Download:

Cites:

Information Journal Paper

Title

THERAPEUTIC POTENTIAL OF CORD BLOOD STEM CELL IN BRAIN DAMAGE OF AN ANIMAL MODEL

Author(s)

Keywords

STEM CELLQ2

HYPOXIC ISCHEMIAQ2

BRAIN DAMAGEQ2

Abstract

BACKGROUND AND OBJECTIVE: Human umbilical cord blood (HUCB) is a rich source of STEM CELLs. The aim of this study was the investigation of the therapeutic effects of these cells on cerebral ischemia in rat.METHODS: This study was carried out on 30 male Wistar rats (100-150 g). They were divided into three groups. Firstly, to create a laboratory model of ischemic stroke, right carotid artery of animals was occluded for 30 minutes in two groups of experimental and sham. Then, mononuclear cells of cord blood were isolated and labeled using bromodeoxyuridine (BrdU) and then 2×105 cells were injected into the experimental group via the tail vein seven day after surgery. Rats in sham group didn’t receive any injection. Control group considered as intact animals. The animals were evaluated for 14 days with modified limb placing and corner turn tests. The transplanted HUCB cells were also detected by immunohistochemistry.FINDINGS: Seven days after surgery, there was a significant recovery in the behavioral performance in the experimental group (12.7 ± 0.26) compared with sham group (10±0.4) and this significant difference continued by the day 14 (15.3±0.31 vs.11.9±0.53, p<0.05). Postural and motor asymmetries, at the days 7 and 14 the experimental group showed a significant decrease in the percentage of right turns in comparison to the sham group (75%±3.07 and 59%±3.14 vs.96%±2.21 and 97%±2.13, p<0.05). In addition, injured volume measurements disclosed a significant decrease in the experimental group compared with sham group (p<0.05).CONCLUSION: Intravenously transplanted HUCB STEM CELL can accelerate neurological function recovery and diminish the lesion size after the HYPOXIC ISCHEMIA. Thus these cells may provide a potential cell candidate for cellbased therapy in stroke.

Cites

No record.

References

No record.

Cite

APA: Copy

NIKRAVESH, M.R., GHAFFARIPOUR, H.A., JALALI, M., HAMIDI ALAMDARI, D., SANCHOOLI, J., & SEGHATOLESLAM, M.. (2012). THERAPEUTIC POTENTIAL OF CORD BLOOD STEM CELL IN BRAIN DAMAGE OF AN ANIMAL MODEL. JOURNAL OF BABOL UNIVERSITY OF MEDICAL SCIENCES (JBUMS), 14(4 (67)), 22-29. SID. https://sid.ir/paper/73393/en

Vancouver: Copy

NIKRAVESH M.R., GHAFFARIPOUR H.A., JALALI M., HAMIDI ALAMDARI D., SANCHOOLI J., SEGHATOLESLAM M.. THERAPEUTIC POTENTIAL OF CORD BLOOD STEM CELL IN BRAIN DAMAGE OF AN ANIMAL MODEL. JOURNAL OF BABOL UNIVERSITY OF MEDICAL SCIENCES (JBUMS)[Internet]. 2012;14(4 (67)):22-29. Available from: https://sid.ir/paper/73393/en

IEEE: Copy

M.R. NIKRAVESH, H.A. GHAFFARIPOUR, M. JALALI, D. HAMIDI ALAMDARI, J. SANCHOOLI, and M. SEGHATOLESLAM, “THERAPEUTIC POTENTIAL OF CORD BLOOD STEM CELL IN BRAIN DAMAGE OF AN ANIMAL MODEL,” JOURNAL OF BABOL UNIVERSITY OF MEDICAL SCIENCES (JBUMS), vol. 14, no. 4 (67), pp. 22–29, 2012, [Online]. Available: https://sid.ir/paper/73393/en

Related Journal Papers