EFFECT OF BERBERINE CHLORIDE ON LONG TERM POTENTIATION (LTP) AT DENTATE GYRUS IN STREPTOZOTOCIN-INDUCED DIABETIC RATS

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KALALIAN MOGHADDAM H.; BALUCHNEJADMOJARAD T.; ROGHANI M.; KHAKSARI M.; RONAGHI A.; MESRIPOUR ALAVIJEH M.

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Journal: JOURNAL OF BABOL UNIVERSITY OF MEDICAL SCIENCES (JBUMS) Year:2014 | Volume:16 | Issue:6 Page(s): 33-42

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Title

EFFECT OF BERBERINE CHLORIDE ON LONG TERM POTENTIATION (LTP) AT DENTATE GYRUS IN STREPTOZOTOCIN-INDUCED DIABETIC RATS

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Keywords

BERBERINEQ2

DIABETESQ2

DENTATE GYRUSQ2

LEARNING AND MEMORYQ2

SYNAPTIC PLASTICITYQ1

Abstract

BACKGROUND AND OBJECTIVE: BERBERINE, an isoquinoline alkaloid is reported to exhibit an anti-diabetic and antioxidant effect. Thus, this research study was conducted, for the first time, to evaluate the effect of BERBERINE on SYNAPTIC PLASTICITY at DENTATE GYRUS (DG) of streptozotocin- induced diabetic rats.METHODS: In this study, the male Wistar rats (n=40) were randomly allocated into five groups: control, control BERBERINE-treated (100 mg/kg), diabetic, BERBERINE-treated diabetic (50, 100 mg/kg) groups. DIABETES was induced intraperinoneally administration at the dose of 55 mg/kg. BERBERINE was orally administered at doses of 50 and 100 mg/kg/day one week after STZ injection for a period of 7 weeks. Blood samples were taken from the tail vein 1, 3, 5, 7 weeks after STZ injection to measure blood glucose levels and Y maze task and passive avoidance test were used for assessment of LEARNING AND MEMORY deficiency. Moreover electrophysiological evaluation including: field excitatory post-synaptic potentials (fEPSP) and Long-term potentiation (LTP) in perforate path-DG synapses was assessed in order to investigate the effect of BERBERINE on SYNAPTIC PLASTICITY. Field excitatory post-synaptic potential (fEPSP) slope and population spike (PS) amplitude were also measured.FINDINGS: Increased blood glucose, reduced weight and short-term spatial memory in diabetic rats treated with BERBERINE were improved (p<0.01). With respect to the control group (192±14), PS amplitude was significantly decreased in the DIABETES group (112±12). In comparison to control group (112±12), chronic treatment with BERBERINE (100 mg/kg) (192±10) improved PS amplitude (p<0.05). In addition fEPSP amplitude was significantly decreased in the DIABETES group (121±6) in comparison to control group (167±11). In comparison to control group (152±6), chronic treatment with BERBERINE (100 mg/kg) (147±3) improved fEPSP amplitude (p<0.05).CONCLUSION: This study showed that BERBERINE treatment in dose dependent manner ameliorates memory impairment and improves SYNAPTIC PLASTICITY in STZ diabetic rats.

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APA: Copy

KALALIAN MOGHADDAM, H., BALUCHNEJADMOJARAD, T., ROGHANI, M., KHAKSARI, M., RONAGHI, A., & MESRIPOUR ALAVIJEH, M.. (2014). EFFECT OF BERBERINE CHLORIDE ON LONG TERM POTENTIATION (LTP) AT DENTATE GYRUS IN STREPTOZOTOCIN-INDUCED DIABETIC RATS. JOURNAL OF BABOL UNIVERSITY OF MEDICAL SCIENCES (JBUMS), 16(6), 33-42. SID. https://sid.ir/paper/73439/en

Vancouver: Copy

KALALIAN MOGHADDAM H., BALUCHNEJADMOJARAD T., ROGHANI M., KHAKSARI M., RONAGHI A., MESRIPOUR ALAVIJEH M.. EFFECT OF BERBERINE CHLORIDE ON LONG TERM POTENTIATION (LTP) AT DENTATE GYRUS IN STREPTOZOTOCIN-INDUCED DIABETIC RATS. JOURNAL OF BABOL UNIVERSITY OF MEDICAL SCIENCES (JBUMS)[Internet]. 2014;16(6):33-42. Available from: https://sid.ir/paper/73439/en

IEEE: Copy

H. KALALIAN MOGHADDAM, T. BALUCHNEJADMOJARAD, M. ROGHANI, M. KHAKSARI, A. RONAGHI, and M. MESRIPOUR ALAVIJEH, “EFFECT OF BERBERINE CHLORIDE ON LONG TERM POTENTIATION (LTP) AT DENTATE GYRUS IN STREPTOZOTOCIN-INDUCED DIABETIC RATS,” JOURNAL OF BABOL UNIVERSITY OF MEDICAL SCIENCES (JBUMS), vol. 16, no. 6, pp. 33–42, 2014, [Online]. Available: https://sid.ir/paper/73439/en

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