Synthesis and antileishmanial activity of antimony (V) complexes of hydroxypyranone and hydroxypyridinone ligands

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Sheikhmoradi Vafa; SABERI SEDIGHEH; SAGHAEI LOTFOLLAH; PESTEHCHIAN NADER; Fassihi Afshin

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Journal: RESEARCH IN PHARMACEUTICAL SCIENCES Year:2018 | Volume:13 | Issue:2 Page(s): 111-120

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Title

Synthesis and antileishmanial activity of antimony (V) complexes of hydroxypyranone and hydroxypyridinone ligands

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Keywords

Antileishmania

Sb (V) complexes

Hydroxypyranone

Hydroxypyridinone

Abstract

A novel series of antimony (V) complexes with the hydroxypyranone and hydroxypyridinone ligands were synthesized and characterized by 1HNMR, FT-IR and electron spin ionization mass spectroscopic (ESI-MS) techniques. The synthesis process involved protection of hydroxyl group followed by the reaction of the intermediate with primary amines and finally deprotection. All compounds were evaluated for in vitro activities against the amastigote and promastigote forms of Leishmania major. Most of the synthesized compounds exhibited good antileishmanial activity against both forms of L. major. IC50 values of the most active compounds; 9d, 9d and 9e, after 24, 48 and 72 h against amastigote model were 15, 12. 5 and 5. 5 μ g/mL, respectively. 9e, 11 and 9e inhibited the promastigote form of parasite after 24, 48 and 72 h with IC50 values of 10, 2 and 1 μ g/mL, respectively.

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APA: Copy

Sheikhmoradi, Vafa, SABERI, SEDIGHEH, SAGHAEI, LOTFOLLAH, PESTEHCHIAN, NADER, & Fassihi, Afshin. (2018). Synthesis and antileishmanial activity of antimony (V) complexes of hydroxypyranone and hydroxypyridinone ligands. RESEARCH IN PHARMACEUTICAL SCIENCES (RPS), 13(2), 111-120. SID. https://sid.ir/paper/738766/en

Vancouver: Copy

Sheikhmoradi Vafa, SABERI SEDIGHEH, SAGHAEI LOTFOLLAH, PESTEHCHIAN NADER, Fassihi Afshin. Synthesis and antileishmanial activity of antimony (V) complexes of hydroxypyranone and hydroxypyridinone ligands. RESEARCH IN PHARMACEUTICAL SCIENCES (RPS)[Internet]. 2018;13(2):111-120. Available from: https://sid.ir/paper/738766/en

IEEE: Copy

Vafa Sheikhmoradi, SEDIGHEH SABERI, LOTFOLLAH SAGHAEI, NADER PESTEHCHIAN, and Afshin Fassihi, “Synthesis and antileishmanial activity of antimony (V) complexes of hydroxypyranone and hydroxypyridinone ligands,” RESEARCH IN PHARMACEUTICAL SCIENCES (RPS), vol. 13, no. 2, pp. 111–120, 2018, [Online]. Available: https://sid.ir/paper/738766/en

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