Cancer Cells Treated by Clusters of Copper Oxide Doped Calcium Silicate

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Mabrouk Mostafa; Kenawy Sayed Hamed; El Bassyouni Gehan El Tabie; Ibrahim Soliman Ahmed Abd El Fattah; Aly Hamzawy Esmat Mahmoud

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Journal: Advanced Pharmaceutical Bulletin Year:2019 | Volume:9 | Issue:1 Page(s): 102-109

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Title

Cancer Cells Treated by Clusters of Copper Oxide Doped Calcium Silicate

Author(s)

Keywords

Copper oxide

Cytotoxicity

Doxycycline hyclate

Chemical precipitation

Abstract

Purpose: Different compositions of Copper oxide (CuO)-doped calcium silicate clusters were used to treat the cancer cells. Methods: The influence of CuO content on the morphology, drug delivering ability, physicochemical properties and Cytotoxicity was investigated. Results: The microcrystalline structure revealed the decrement of the size from (20-36 nm) to (5-7 nm) depending on the copper content percentages. Drug delivering ability of Doxycycline hyclate (Dox) was down regulated from 58% to 28%in the presence of the CuO. The inclusion of CuO and Dox didn’ t show any remarkable changes on the physicochemical properties of the CuO-doped calcium silicate nanoparticles. Conclusion: The CuO-doped calcium silicate sample (5 weight %) exhibited great Cytotoxicity against the tested cell lines compared to the CuO-free sample. CuO-doped materials displayed significant anticancer effect; this sheds light on its implication in the treatment of cancer.

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APA: Copy

Mabrouk, Mostafa, Kenawy, Sayed Hamed, El Bassyouni, Gehan El Tabie, Ibrahim Soliman, Ahmed Abd El Fattah, & Aly Hamzawy, Esmat Mahmoud. (2019). Cancer Cells Treated by Clusters of Copper Oxide Doped Calcium Silicate. ADVANCED PHARMACEUTICAL BULLETIN, 9(1), 102-109. SID. https://sid.ir/paper/740234/en

Vancouver: Copy

Mabrouk Mostafa, Kenawy Sayed Hamed, El Bassyouni Gehan El Tabie, Ibrahim Soliman Ahmed Abd El Fattah, Aly Hamzawy Esmat Mahmoud. Cancer Cells Treated by Clusters of Copper Oxide Doped Calcium Silicate. ADVANCED PHARMACEUTICAL BULLETIN[Internet]. 2019;9(1):102-109. Available from: https://sid.ir/paper/740234/en

IEEE: Copy

Mostafa Mabrouk, Sayed Hamed Kenawy, Gehan El Tabie El Bassyouni, Ahmed Abd El Fattah Ibrahim Soliman, and Esmat Mahmoud Aly Hamzawy, “Cancer Cells Treated by Clusters of Copper Oxide Doped Calcium Silicate,” ADVANCED PHARMACEUTICAL BULLETIN, vol. 9, no. 1, pp. 102–109, 2019, [Online]. Available: https://sid.ir/paper/740234/en

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