Cell Timer/Cell Clock (STUDY BREAK)

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GHADIRI HAMED; Alavi Sana; DABIRMANESH BAHAREH; Moriyama Kenji; KHAJEH KHOSRO; Masai Hisao

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

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Journal: Iranian Biomedical Journal Year:2018 | Volume:22 | Issue:6 Page(s): 360-361

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Title

Cell Timer/Cell Clock (STUDY BREAK)

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Abstract

Like the biological clock in the body, replication of each cell type (even different cells of the same organism) follows a timing program. Abnormal function of this timer could be an alarm for a disease like cancer. DNA replication starts from a specific point on the chromosome that is called the origin of replication. In contrast to prokaryotes in which DNA replication starts from a single origin, eukaryotic DNA replication starts from many origins scattered along the chromosomes. Budding yeast contains 300 origins, whereas fission yeast has 1, 100, and the numbers of replication origins for human increase to over 20, 000. These origins are fired in a coordinated manner, and there are spatial and temporal disciplines for this process, which happens in the S phase of the cell cycle. It was known that eukaryotic cells prepare all these potential origins during the G1 phase of the cell cycle but utilize only a portion of these origins during S phase. Furthermore, firing some of these origins are delayed until the mid and late phases of the S phase...

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