Image-Based Neonatal Hyperbilirubinemia Screening after Hospital Discharge

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DONG Xiaoyue; Sun Xiaofang; YU Zhangbin; HAN Shuping

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Journal Paper

Paper Information

Journal: Iranian Journal of Public Health Year:2020 | Volume:49 | Issue:6 Page(s): 1079-1086

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Title

Image-Based Neonatal Hyperbilirubinemia Screening after Hospital Discharge

Author(s)

DONG Xiaoyue | Sun Xiaofang | YU Zhangbin | HAN Shuping | Issue Writer Certificate

Keywords

Jaundice

Hyperbilirubinemia

Postnatal

Automatic image-based

Abstract

Background: Newborn infants who are risk for severe Hyperbilirubinemia and cared at home should be monitored for progression of Jaundice. We aimed to verify if a smart phone application (BiliScan Inc), which uses automated imaging for bilirubin (AIB), can be used to estimate total serum bilirubin (TSB) levels at home. Methods: A convenience sample of 1038 “ healthy” infants in China were prospectively enrolled to a singlecenter study in 2016. Correlations between AIB and TcB measurements were correlated to TB measurements. Bias and imprecision of AIB measurements were determined using Bland-Altman analysis. The diagnostic value of AIB was compared by the area-under-curve (AUC) values of receiver operator characteristic (ROC) curves. Results: The best correlation and AUC for AIB were at the sternum, both with values of 0. 76. We truncated performances to 369 TB values >5 and <15 mg/dL, and sternal AIB showed the best correlation to TB (r =0. 5, P<0. 0001). The AUC for this range was 0. 54. However, from a subset of 200 AIB values >13. 5 mg/dL (n=369 babies), the sensitivity and negative predictive value (NPV) were 100% with a specificity of 50%. Furthermore, Bland-Altman analyses showed a bias and imprecision of AIB and TcB when TB was >13. 5 and <15 mg/dL. Conclusion: The use of AIB may be a potentially useful screening device for neonatal Jaundice. Its performance requires additional improvements for accurate measurements across wider ranges of TB levels.

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APA: Copy

DONG, Xiaoyue, Sun, Xiaofang, YU, Zhangbin, & HAN, Shuping. (2020). Image-Based Neonatal Hyperbilirubinemia Screening after Hospital Discharge. IRANIAN JOURNAL OF PUBLIC HEALTH, 49(6), 1079-1086. SID. https://sid.ir/paper/747936/en

Vancouver: Copy

DONG Xiaoyue, Sun Xiaofang, YU Zhangbin, HAN Shuping. Image-Based Neonatal Hyperbilirubinemia Screening after Hospital Discharge. IRANIAN JOURNAL OF PUBLIC HEALTH[Internet]. 2020;49(6):1079-1086. Available from: https://sid.ir/paper/747936/en

IEEE: Copy

Xiaoyue DONG, Xiaofang Sun, Zhangbin YU, and Shuping HAN, “Image-Based Neonatal Hyperbilirubinemia Screening after Hospital Discharge,” IRANIAN JOURNAL OF PUBLIC HEALTH, vol. 49, no. 6, pp. 1079–1086, 2020, [Online]. Available: https://sid.ir/paper/747936/en

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