EFFECTS OF PAPAVER RHOEAS EXTRACT ON THE EXPRESSION AND DEVELOPMENT OF MORPHINE-INDUCED BEHAVIORAL SENSITIZATION IN MICE

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SAHRAEI HEDAYAT; FAGHIH MONZAVI Z.; FATEMI SEYED MOHAMMAD REZA; PASHAEIRAD SH.; SHAMS J.; GHOSHOUNI H.

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Journal: Physiology and Pharmacology Year:2006 | Volume:9 | Issue:2 Page(s): 151-158

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Title

EFFECTS OF PAPAVER RHOEAS EXTRACT ON THE EXPRESSION AND DEVELOPMENT OF MORPHINE-INDUCED BEHAVIORAL SENSITIZATION IN MICE

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Keywords

MORPHINEQ3

BEHAVIORAL SENSITIZATION AND TOLERANCEQ4

MOUSEQ4

PAPAVER RHOEASQ3

Abstract

Opioid addiction is one of the main problems for the health services. In the present study, the effects of water-alcohol extract of PAPAVER RHOEAS on the expression and acquisition of MORPHINE-induced behavioral sensitization were investigated.Mice became sensitized (5 mg/kg, once daily, for three consecutive days; s.c.) or tolerate (50 mg/kg, twice daily for three consecutive days; s.c.) to MORPHINE and the extract before the MORPHINE injection (acquisition) or on the test day (expression) was administrated to them. In a pilot study, different doses of MORPHINE and the extract were administered to the animals in order to evaluate if the drugs can produce any locomotion effects.Results showed that: subcutaneous (s.c.) administration of MORPHINE (0.5-50 mg/kg) increased locomotor activity in the animals. The response was more significant in dose 50 mg/kg of MORPHINE. On the other hand, intraperitoneal (i.p.) administration of the plant extract (25, 50 and 100 mg/kg) did not show any effect. Daily injection of MORPHINE (5 mg/kg; s.c.) for three consecutive days and then five days resting induced sensitization in the animals, so that the MORPHINE sensitized animals showed an extra ordinary response to the ineffective dose of MORPHINE (5 mg/kg; s.c.). Injection of extract (25, 50 and 100 mg/kg, i.p.) 30 min before the MORPHINE administration decreased the acquisition of MORPHINE-induced behavioral sensitization. Administration of the plant extract (25, 50 and 100 mg/kg, i.p.) 30 min before the test, also decreased the expression of MORPHINE-induced behavioral sensitization. Injection of MORPHINE (50 mg/kg; twice daily) for three consecutive days induced tolerance in the animals, so that the MORPHINE tolerated animals did not show any response to the effective dose of MORPHINE (50 mg/kg; s.c.). Injection of extract (25, 50 and 100 mg/kg, i.p.) 30 min before the MORPHINE administration decreased the acquisition of MORPHINE-induced tolerance. Administration of the plant extract (25, 50 and 100 mg/kg, i.p.) 30 min before the test, increased the expression of MORPHINE-induced behavioral tolerance.It could be concluded that the extract of PAPAVER RHOEAS can reduced both the acquisition and expression of MORPHINE-induced behavioral sensitization -and also the acquisition of MORPHINE tolerance but enhances the expression of MORPHINE tolerance in mice which may be true in the human.

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APA: Copy

SAHRAEI, HEDAYAT, FAGHIH MONZAVI, Z., FATEMI, SEYED MOHAMMAD REZA, PASHAEIRAD, SH., SHAMS, J., & GHOSHOUNI, H.. (2006). EFFECTS OF PAPAVER RHOEAS EXTRACT ON THE EXPRESSION AND DEVELOPMENT OF MORPHINE-INDUCED BEHAVIORAL SENSITIZATION IN MICE. PHYSIOLOGY AND PHARMACOLOGY, 9(2), 151-158. SID. https://sid.ir/paper/74938/en

Vancouver: Copy

SAHRAEI HEDAYAT, FAGHIH MONZAVI Z., FATEMI SEYED MOHAMMAD REZA, PASHAEIRAD SH., SHAMS J., GHOSHOUNI H.. EFFECTS OF PAPAVER RHOEAS EXTRACT ON THE EXPRESSION AND DEVELOPMENT OF MORPHINE-INDUCED BEHAVIORAL SENSITIZATION IN MICE. PHYSIOLOGY AND PHARMACOLOGY[Internet]. 2006;9(2):151-158. Available from: https://sid.ir/paper/74938/en

IEEE: Copy

HEDAYAT SAHRAEI, Z. FAGHIH MONZAVI, SEYED MOHAMMAD REZA FATEMI, SH. PASHAEIRAD, J. SHAMS, and H. GHOSHOUNI, “EFFECTS OF PAPAVER RHOEAS EXTRACT ON THE EXPRESSION AND DEVELOPMENT OF MORPHINE-INDUCED BEHAVIORAL SENSITIZATION IN MICE,” PHYSIOLOGY AND PHARMACOLOGY, vol. 9, no. 2, pp. 151–158, 2006, [Online]. Available: https://sid.ir/paper/74938/en

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