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Information Journal Paper

Title

THE EFFECT OF TOPICAL NIFEDIPINE ON WOUND HEALING IN DIABETIC RATS

Pages

  199-204

Abstract

 The aim of this study was to determine the effect of NIFEDIPINE cream on WOUND HEALING in diabetic rats. For this purpose, 36 male Wistar rats (180-200 g) were randomly divided into four groups. At first, two groups of rats were made diabetic using streptozotocin (70-80 mg/Kg; i.p.) and the other two groups were considered as control. After observing symptoms of diabetes including increased blood sugar (250-300 mg/dl), a wound with a diameter of 1.5 cm was made on the dorsum SKIN of each rat under sterile conditions. NIFEDIPINE cream (3%) was then applied to one group of diabetic rats and one group of normal rats. The other two groups were treated with placebo. Thereafter, biopsies were taken from the healing regions at the third, seventh, and the wound closure days. The microscopic findings showed that there was a significant difference between the group receiving NIFEDIPINE and the group treated with placebo regarding both inflammation and growth phases (P<0.0005). In addition, there was a significant difference between the diabetic groups for both phases (P<0.001), while there was only a significant difference between the two control groups for the inflammation phase (P=0.05). Therefore, it can be concluded that NIFEDIPINE cream is effective in WOUND HEALING.

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    Cite

    APA: Copy

    EBADI, A., GHOSHOUNI, H., & CHERAGHALI, A.. (2002). THE EFFECT OF TOPICAL NIFEDIPINE ON WOUND HEALING IN DIABETIC RATS. PHYSIOLOGY AND PHARMACOLOGY, 5(2), 199-204. SID. https://sid.ir/paper/74975/en

    Vancouver: Copy

    EBADI A., GHOSHOUNI H., CHERAGHALI A.. THE EFFECT OF TOPICAL NIFEDIPINE ON WOUND HEALING IN DIABETIC RATS. PHYSIOLOGY AND PHARMACOLOGY[Internet]. 2002;5(2):199-204. Available from: https://sid.ir/paper/74975/en

    IEEE: Copy

    A. EBADI, H. GHOSHOUNI, and A. CHERAGHALI, “THE EFFECT OF TOPICAL NIFEDIPINE ON WOUND HEALING IN DIABETIC RATS,” PHYSIOLOGY AND PHARMACOLOGY, vol. 5, no. 2, pp. 199–204, 2002, [Online]. Available: https://sid.ir/paper/74975/en

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