EVALUATION OF THE EFFECT OF ASCORBIC ACID ON THE ACQUISITION AND EXPRESSION OF MORPHINE-INDUCED CONDITIONED PLACE PREFERENCE IN MICE

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SAHRAEI HEDAYAT; NASIRI ALI; DASTAMOOZ A.; GHOSHOUNI H.; HOSSEIN MARDI L.; YARI M.; ZARDOUZ H.

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Journal: Physiology and Pharmacology Year:2002 | Volume:5 | Issue:2 Page(s): 205-212

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Title

EVALUATION OF THE EFFECT OF ASCORBIC ACID ON THE ACQUISITION AND EXPRESSION OF MORPHINE-INDUCED CONDITIONED PLACE PREFERENCE IN MICE

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Keywords

MORPHINEQ3

ASCORBIC ACIDQ3

CONDITIONED PLACE PREFERENCEQ4

MICEQ3

Abstract

Increased activity of mesolimbic dopaminergic pathway within ventral tegmental area (VTA) by MORPHINE results in psychologic dependence. It is argued that function of dopamine receptors could be affected by ASCORBIC ACID (AA). Furthermore, AA can decrease the withdrawal syndrome signs in addicted animals and may postpone the development of MORPHINE dependence. In the present study, the possible role of AA on acquisition and expression of MORPHINE-induced CONDITIONED PLACE PREFERENCE (CPP) was investigated in MICE.In this study, female Swiss-Webster MICE (20-25 g) were used and a biased method was performed for induction of CPP. The results showed that subcutaneous injection of MORPHINE (1-10 mg/Kg) induced CPP in a dose-dependent manner. In addition, intraperitoneal administration of AA (1-1000 mg/Kg) failed to induce any aversion or preference effects. Meanwhile, administration of AA (I -1000 mg/Kg) on the test day reduced the MORPHINE effect, but not in a dose-dependent manner. The chronic administration of AA (1-1000 mg/Kg; i.p.) reduced the MORPHINE effect as well. Therefore, it can be concluded that motivational effects of MORPHINE can be affected dramatically by AA, but the drug may not act via a single mechanism.

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APA: Copy

SAHRAEI, HEDAYAT, NASIRI, ALI, DASTAMOOZ, A., GHOSHOUNI, H., HOSSEIN MARDI, L., YARI, M., & ZARDOUZ, H.. (2002). EVALUATION OF THE EFFECT OF ASCORBIC ACID ON THE ACQUISITION AND EXPRESSION OF MORPHINE-INDUCED CONDITIONED PLACE PREFERENCE IN MICE. PHYSIOLOGY AND PHARMACOLOGY, 5(2), 205-212. SID. https://sid.ir/paper/74978/en

Vancouver: Copy

SAHRAEI HEDAYAT, NASIRI ALI, DASTAMOOZ A., GHOSHOUNI H., HOSSEIN MARDI L., YARI M., ZARDOUZ H.. EVALUATION OF THE EFFECT OF ASCORBIC ACID ON THE ACQUISITION AND EXPRESSION OF MORPHINE-INDUCED CONDITIONED PLACE PREFERENCE IN MICE. PHYSIOLOGY AND PHARMACOLOGY[Internet]. 2002;5(2):205-212. Available from: https://sid.ir/paper/74978/en

IEEE: Copy

HEDAYAT SAHRAEI, ALI NASIRI, A. DASTAMOOZ, H. GHOSHOUNI, L. HOSSEIN MARDI, M. YARI, and H. ZARDOUZ, “EVALUATION OF THE EFFECT OF ASCORBIC ACID ON THE ACQUISITION AND EXPRESSION OF MORPHINE-INDUCED CONDITIONED PLACE PREFERENCE IN MICE,” PHYSIOLOGY AND PHARMACOLOGY, vol. 5, no. 2, pp. 205–212, 2002, [Online]. Available: https://sid.ir/paper/74978/en

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