MICROINFUSION OF TNFα AND ITS ANTIBODY INTO LOCUS COERULEUS MODIFIES NERVE INJURY INDUCED THERMAL HYPERALGESIA AND MECHANICAL ALLODYNIA

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ROHAMPOUR KAMBIZ; MANAHEJI HOMA; SEMNANIAN SAEED; AZIZI HOSSEIN

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Journal: Physiology and Pharmacology Year:2011 | Volume:14 | Issue:4 Page(s): 398-405

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Title

MICROINFUSION OF TNFα AND ITS ANTIBODY INTO LOCUS COERULEUS MODIFIES NERVE INJURY INDUCED THERMAL HYPERALGESIA AND MECHANICAL ALLODYNIA

Author(s)

ROHAMPOUR KAMBIZ | MANAHEJI HOMA | SEMNANIAN SAEED | AZIZI HOSSEIN | Issue Writer Certificate

Keywords

NEUROPATHIC PAINQ3

TNFαQ3

ALLODYNIAQ3

HYPERALGESIAQ3

Abstract

Introduction: Glial activation and secretion of cytokines at the spinal level is known as part of chronic pain pathogenesis. Although changes in TNFa at the supraspinal level are reported during chronic pain, its exact role and site of action remain to be elucidated. We investigated the effect of microinfusion of TNFa into the LC in a rat model of NEUROPATHIC PAIN.Methods: Male Wistar rats were cannulated in the LC. The cannula was connected to an Alzet mini-osmotic pump, which was filled by the drug (vehicle, TNFa or TNFa-antibody) and placed subcutaneously behind the neck. Twenty four-48 hours after cannulation, a chronic constriction injury (CCI) surgery was performed on the contralateral sciatic nerve. HYPERALGESIA and ALLODYNIA symptoms were assessed 2, 4, 6, 8, 10 and 12 days after CCI.Results: Microinfusion of TNFa (100ng/day) into the LC significantly exacerbated the HYPERALGESIA in rat models of NEUROPATHIC PAIN on days 2 and 8 after CCI. On the other hand, microinfusion of TNFa antibody (250ng/day) decreased the symptoms of HYPERALGESIA on days 2, 4, 6, 8, 10 and 14. TNFa antibody also significantly alleviated the CCIinduced ALLODYNIA.Conclusion: These data suggest that alterations of TNFa levels in the LC play a crucial role in the development and maintenance of NEUROPATHIC PAIN.

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APA: Copy

ROHAMPOUR, KAMBIZ, MANAHEJI, HOMA, SEMNANIAN, SAEED, & AZIZI, HOSSEIN. (2011). MICROINFUSION OF TNFα AND ITS ANTIBODY INTO LOCUS COERULEUS MODIFIES NERVE INJURY INDUCED THERMAL HYPERALGESIA AND MECHANICAL ALLODYNIA. PHYSIOLOGY AND PHARMACOLOGY, 14(4), 398-405. SID. https://sid.ir/paper/74986/en

Vancouver: Copy

ROHAMPOUR KAMBIZ, MANAHEJI HOMA, SEMNANIAN SAEED, AZIZI HOSSEIN. MICROINFUSION OF TNFα AND ITS ANTIBODY INTO LOCUS COERULEUS MODIFIES NERVE INJURY INDUCED THERMAL HYPERALGESIA AND MECHANICAL ALLODYNIA. PHYSIOLOGY AND PHARMACOLOGY[Internet]. 2011;14(4):398-405. Available from: https://sid.ir/paper/74986/en

IEEE: Copy

KAMBIZ ROHAMPOUR, HOMA MANAHEJI, SAEED SEMNANIAN, and HOSSEIN AZIZI, “MICROINFUSION OF TNFα AND ITS ANTIBODY INTO LOCUS COERULEUS MODIFIES NERVE INJURY INDUCED THERMAL HYPERALGESIA AND MECHANICAL ALLODYNIA,” PHYSIOLOGY AND PHARMACOLOGY, vol. 14, no. 4, pp. 398–405, 2011, [Online]. Available: https://sid.ir/paper/74986/en

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