EFFECT OF MINOCYCLINE ON AMYGDALA KINDLING ACQUISITION IN RATS

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BEHESHTI NASR SEYED MEHDI; MOGHIMI ALI; MOHAMMAD ZADEH M.

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Journal: Physiology and Pharmacology Year:2012 | Volume:16 | Issue:3 Page(s): 222-230

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Title

EFFECT OF MINOCYCLINE ON AMYGDALA KINDLING ACQUISITION IN RATS

Author(s)

BEHESHTI NASR SEYED MEHDI | MOGHIMI ALI | MOHAMMAD ZADEH M. | Issue Writer Certificate

Keywords

SEIZUREQ3

KINDLINGQ3

MINOCYCLINEQ2

RATQ3

Abstract

Introduction: MINOCYCLINE is a derivative of tetracycline that has anti-inflammatory, antiappoptic, antioxidant and neuroprotective effects. Since there is a relationship between cell death and SEIZURE, the aim of this study was to examine the role of MINOCYCLINE in development of amygdala KINDLING in Wistar RATs.Methods: In this study, 21 RATs were divided into three groups. After stereotaxic surgery and 1 week recovery period, RATs received KINDLING stimulations (twice daily at 6 hour intervals). Group 1 (n=7) received daily KINDLING stimulations.Groups 2 (n=7) and 3 (n=7) received saline (1 ml/kg) and MINOCYCLINE (25 mg/kg), respectively, 60 min before KINDLING stimulation. Cumulative After discharge Duration (ADD), Cumulative SEIZURE duration (SD) and SEIZURE Stage (SS) were recorded and compared to the control group.Results: In group 3, intraperitoneal administration of MINOCYCLINE for 10 days significantly reduced cumulative ADD (control group: 907.2±64.5, MINOCYCLINE group: 717.8±67.9) [F(18, 216)=3.5, p<0.001], and cumulative SD (control group: 999.4±79.8, MINOCYCLINE group: 776.1±77) [F(19, 228)=3.8, p<0.001] compared to control group (group 2). It also significantly increased the mean number of stimulations to achieve the SEIZURE stage 3 (control group: 7.2±0.6, MINOCYCLINE group: 11±1) (P<0.05), and 5 (control group: 10.7±0.1, MINOCYCLINE group: 18.7±0.3) (P<0.001).Conclusion: According to the obtained results, application of MINOCYCLINE increases the time required for amygdala KINDLING and may have anticonvulsant effects.

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APA: Copy

BEHESHTI NASR, SEYED MEHDI, MOGHIMI, ALI, & MOHAMMAD ZADEH, M.. (2012). EFFECT OF MINOCYCLINE ON AMYGDALA KINDLING ACQUISITION IN RATS. PHYSIOLOGY AND PHARMACOLOGY, 16(3), 222-230. SID. https://sid.ir/paper/75003/en

Vancouver: Copy

BEHESHTI NASR SEYED MEHDI, MOGHIMI ALI, MOHAMMAD ZADEH M.. EFFECT OF MINOCYCLINE ON AMYGDALA KINDLING ACQUISITION IN RATS. PHYSIOLOGY AND PHARMACOLOGY[Internet]. 2012;16(3):222-230. Available from: https://sid.ir/paper/75003/en

IEEE: Copy

SEYED MEHDI BEHESHTI NASR, ALI MOGHIMI, and M. MOHAMMAD ZADEH, “EFFECT OF MINOCYCLINE ON AMYGDALA KINDLING ACQUISITION IN RATS,” PHYSIOLOGY AND PHARMACOLOGY, vol. 16, no. 3, pp. 222–230, 2012, [Online]. Available: https://sid.ir/paper/75003/en

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