THE ROLE OF CENTRAL Α-ADRENERGIC RECEPTORS ON IMIPRAMINE-INDUCED ANTINOCICEPTION AS REVEALED BY FORMALIN TEST IN RAT

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SAHEBGHARANI M.; SAMINI M.; ZARINDAST M.R.

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Journal: Physiology and Pharmacology Year:2001 | Volume:4 | Issue:2 Page(s): 131-144

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Title

THE ROLE OF CENTRAL Α-ADRENERGIC RECEPTORS ON IMIPRAMINE-INDUCED ANTINOCICEPTION AS REVEALED BY FORMALIN TEST IN RAT

Author(s)

SAHEBGHARANI M. | SAMINI M. | ZARINDAST M.R. | Issue Writer Certificate

Keywords

Α-ADRENOCEPTORQ4

IMIPRAMINEQ4

FORMALIN TESTQ4

Abstract

In this study, the effect of Α-ADRENOCEPTOR agents on IMIPRAMINE-induced antinociception was investigated using FORMALIN TEST. Intraperitoneal (IP) administration of IMIPRAMINE at different doses (10-80 mg/kg) induced antinociception in both phases of FORMALIN TEST. In addition, intracerebroventricular (ICV) injection of IMIPRAMINE (1, 5, and 10 µg/rat) did not elicit any effect, although ICV injection of clonidine, an aradrenoceptor agonist at doses of 0.05-0.8 µg/rat also elicited antinociception in both phases of the test. Furthermore, clonidine increases the antinociception induced by IMIPRAMINE and yohimbine, an α2-aradrenoceptor antagonist at a dose of 2 µg/rat (ICV) reduced the response to IMIPRAMINE at a low dose (10 mg/kg, IP) and clonidine (0.05 µg/rat, ICV), but did not alter the response induced by higher doses of IMIPRAMINE (20 and 40 mg/kg) alone or in combination with clonidine. Yohimbine by itself elicited no response. Meanwhile, phenylephrine (0.07-1.5 µg/rat, ICV), a α1-adrenoceptor agonist induced antinociception in both phases of FORMALIN TEST, but did not alter the IMIPRAMINE-induced antinociception. The α1-adrenoceptor antagonist, prazocin neither elicited antinociception nor altered the IMIPRAMINE response. Yohimbine (2 µg/rat, ICV) in combination with prazocin (0.5 µg/rat, ICV) further inhibited the response for IMIPRAMINE alone or in combination with clonidine. Taken together, it is concluded that aradrenoceptor-mediated mechanism might be involved in the development of IMIPRAMINE-induced antinociception.

Cites

THE EFFECT OF CONTINUED DIABETES ON THE FORMALIN- INDUCED PAIN AND BACLOFEN ANALGESIA IN RAT

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APA: Copy

SAHEBGHARANI, M., SAMINI, M., & ZARINDAST, M.R.. (2001). THE ROLE OF CENTRAL Α-ADRENERGIC RECEPTORS ON IMIPRAMINE-INDUCED ANTINOCICEPTION AS REVEALED BY FORMALIN TEST IN RAT. PHYSIOLOGY AND PHARMACOLOGY, 4(2), 131-144. SID. https://sid.ir/paper/75022/en

Vancouver: Copy

SAHEBGHARANI M., SAMINI M., ZARINDAST M.R.. THE ROLE OF CENTRAL Α-ADRENERGIC RECEPTORS ON IMIPRAMINE-INDUCED ANTINOCICEPTION AS REVEALED BY FORMALIN TEST IN RAT. PHYSIOLOGY AND PHARMACOLOGY[Internet]. 2001;4(2):131-144. Available from: https://sid.ir/paper/75022/en

IEEE: Copy

M. SAHEBGHARANI, M. SAMINI, and M.R. ZARINDAST, “THE ROLE OF CENTRAL Α-ADRENERGIC RECEPTORS ON IMIPRAMINE-INDUCED ANTINOCICEPTION AS REVEALED BY FORMALIN TEST IN RAT,” PHYSIOLOGY AND PHARMACOLOGY, vol. 4, no. 2, pp. 131–144, 2001, [Online]. Available: https://sid.ir/paper/75022/en

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