BETA-ADRENOCEPTOR-MEDIATED RESPONSIVENESS OF HUMAN INTERNAL MAMMARY ARTERY

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SHAFIEE M.; MAHMOUDIAN M.; OMRANI GH.

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Paper Information

Journal: Physiology and Pharmacology Year:2001 | Volume:4 | Issue:2 Page(s): 161-174

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Information Journal Paper

Title

BETA-ADRENOCEPTOR-MEDIATED RESPONSIVENESS OF HUMAN INTERNAL MAMMARY ARTERY

Author(s)

SHAFIEE M. | MAHMOUDIAN M. | OMRANI GH. | Issue Writer Certificate

Keywords

HUMAN INTERNAL MAMMARY ARTERYQ4

BETA-ADRENOCEPTORSQ4

ISOPROTERENOLQ4

BRL 37344Q4

CYANOPINDOLOLQ4

Abstract

The internal mammary artery (IMA) is currently the preferred conduit for myocardial revascularization. However, pre-operative vasospasm and a hypoperfusion state during maximal exercise may limit its use as a bypass graft. The mechanism of spasm has not been clearly defined. Since ß-adrenoceptor activation plays a major role in vasorelaxation, the present study was carried out to investigate the ß-adrenoceptor responsiveness of human IMA smooth muscle.For this purpose, IMA was obtained from patients with atherosclerosis of coronary artery whom have undergone coronary artery bypass. The endothelium denuded rings of IMA were placed on platinum wires (L-shaped) in a Krebs solution containing tissue bath, and were connected to an isometric transducer. It was found out that ISOPROTERENOL produced a dose-dependent relaxation in endothelium-denuded MA segments, precontracted with phenylephrine (maximal relaxation was 46.33 ±5.45%). ISOPROTERENOL-induced relaxation was inhibited by atenolol (10-6M) and propranolol (2 x 10-7M). While atenolol-induced inhibition was partial, propranolol-induced inhibition was complete in a majority of the segments. BRL 37344, a selective ß3-adrenoceptor agonist, produced a dose-dependent relaxation in phenylephrine precontracted rings of endothelium-denuded IMA (maximal relaxation was 40.35 ±4.07%). CYANOPINDOLOL, a ß-adrenoceptor partial agonist, produced a marked relaxation in endothelium-denuded IMA rings, precontracted with phenylephrine (maximal relaxation was 58.65±6.2%). CYANOPINDOLOL-induced relaxation was resistant to blockade by propranolol (2 x 10-7 M). In addition, spontaneous contractions of IMA rings were observed in some of the cases that were inhibited by ISOPROTERENOL and BRL 37344. This observation may indicate the important role of ß3-adrenoceptor activation in prevention of human IMA spasm.Therefore, it is concluded that human IMA smooth muscle possesses both ß1-and ß2-radrenoceptors. The existence of ß3-adrenoceptorip this tissue is also suggested.

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APA: Copy

SHAFIEE, M., MAHMOUDIAN, M., & OMRANI, GH.. (2001). BETA-ADRENOCEPTOR-MEDIATED RESPONSIVENESS OF HUMAN INTERNAL MAMMARY ARTERY. PHYSIOLOGY AND PHARMACOLOGY, 4(2), 161-174. SID. https://sid.ir/paper/75025/en

Vancouver: Copy

SHAFIEE M., MAHMOUDIAN M., OMRANI GH.. BETA-ADRENOCEPTOR-MEDIATED RESPONSIVENESS OF HUMAN INTERNAL MAMMARY ARTERY. PHYSIOLOGY AND PHARMACOLOGY[Internet]. 2001;4(2):161-174. Available from: https://sid.ir/paper/75025/en

IEEE: Copy

M. SHAFIEE, M. MAHMOUDIAN, and GH. OMRANI, “BETA-ADRENOCEPTOR-MEDIATED RESPONSIVENESS OF HUMAN INTERNAL MAMMARY ARTERY,” PHYSIOLOGY AND PHARMACOLOGY, vol. 4, no. 2, pp. 161–174, 2001, [Online]. Available: https://sid.ir/paper/75025/en

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