TREATMENT EFFECT OF GABA ON IMPROVE TYPE ONE DIABETES IN NOD MICE

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SOLTANI NEPTON; KESHAVARZ MANSOOR; WANG QINGHUA

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Journal: Physiology and Pharmacology Year:2009 | Volume:13 | Issue:3 Page(s): 288-296

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Title

TREATMENT EFFECT OF GABA ON IMPROVE TYPE ONE DIABETES IN NOD MICE

Author(s)

SOLTANI NEPTON | KESHAVARZ MANSOOR | WANG QINGHUA | Issue Writer Certificate

Keywords

TYPE ONE DIABETESQ3

GABAQ3

C-PEPTIDEQ3

GLOCAGONQ3

GLUCOSEQ3

NOD MICEQ3

Abstract

Introduction: Gama amino butyric acid (GABA) is the major inhibitory neurotransmitter in the mammalian nervous system. The concentration of GABA and the number of GABA cell secretion decrease in diabetic patient and experimental diabetes model. The reported effects of GABA activation on insulin secretion from beta cells have been controversial. In this study we investigated if GABA administration in animal diabetes model can change insulin and glucagon secretion and improve some diabetic symptoms.Methods: Twenty fourth-week old NOD mi (Non obese diabetic mice) ce were used. Two months after diabetic induction animals were divided into the two groups. One group received 200 mmol of GABA and the other group received phosphate buffer solution (PBS) for one month.Results: GABA administration could significantly decrease plasma GLUCOSE and glucagon level, water consumption and urine volume and body fat distribution in the mesenteric bed and abdominal wall. It also could increase plasma Cpeptide level and it has not effect on food intake.Conclusion: NOD MICE is very good genetically model for TYPE ONE DIABETES and GABA administration in this mice could treatment some of diabetic symptom. It seems may be we could use of GABA for treatment of diabetic symptom in future.

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APA: Copy

SOLTANI, NEPTON, KESHAVARZ, MANSOOR, & WANG, QINGHUA. (2009). TREATMENT EFFECT OF GABA ON IMPROVE TYPE ONE DIABETES IN NOD MICE. PHYSIOLOGY AND PHARMACOLOGY, 13(3), 288-296. SID. https://sid.ir/paper/75060/en

Vancouver: Copy

SOLTANI NEPTON, KESHAVARZ MANSOOR, WANG QINGHUA. TREATMENT EFFECT OF GABA ON IMPROVE TYPE ONE DIABETES IN NOD MICE. PHYSIOLOGY AND PHARMACOLOGY[Internet]. 2009;13(3):288-296. Available from: https://sid.ir/paper/75060/en

IEEE: Copy

NEPTON SOLTANI, MANSOOR KESHAVARZ, and QINGHUA WANG, “TREATMENT EFFECT OF GABA ON IMPROVE TYPE ONE DIABETES IN NOD MICE,” PHYSIOLOGY AND PHARMACOLOGY, vol. 13, no. 3, pp. 288–296, 2009, [Online]. Available: https://sid.ir/paper/75060/en

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